PMID: 6172984Dec 1, 1981Paper

Hormonal activation of ornithine decarboxylase in embryonic chick pelvic cartilage

The American Journal of Physiology
W M Burch, H E Lebovitz

Abstract

We assessed whether hormones and metabolic factors known to stimulate anabolic processes in the embryonic chick pelvic cartilage would stimulate ornithine decarboxylase (ODC) activity. In vitro organ culture of these pelvic cartilages in time-course experiments with N(6)-monobutyryl cyclic AMP (BtcAMP), insulin, and 5% rat serum demonstrated maximal stimulation of ODC activity between 4 and 6 h with each factor. However, at 2 h insulin and serum significantly stimulated ODC activity (P less than 0.05) and BtcAMP did not. ODC was stimulated above control (100%) with the following factors: parathyroid hormone (PTH) (555 +/- 15%), BtcAMP (324 +/- 34%), 1-methyl-3-isobutylxanthine (MIX) (223 +/- 6%), prostaglandin E1 (PGE1) (227 +/- 15%), 3,3',5-triiodothyronine (T3) (184 +/- 22%), insulin (182 +/- 14%), multiplication-stimulating activity (MSA) (178 +/- 6%), 5% rat serum (253 +/- 57%). THe increase in ODC activity seen with BtcAMP and insulin was not due to a change in Km or a decreased rate of degradation of the enzyme. Actinomycin D (1 microgram/ml) inhibited stimulation of ODC activity by T3 and the cyclic AMP-mediated factors (PTH, BtcAMP, MIX, PGE1), but had only minimal effects on ODC stimulation by insulin, MSA, or serum. A...Continue Reading

References

Feb 15, 1977·The Biochemical Journal·P D ConroyJ J Pointon
Feb 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·T K Audhya, K D Gibson
Apr 2, 1976·Biochimica Et Biophysica Acta·M K DreznerH E Lebovitz
Jan 1, 1978·Advances in Enzyme Regulation·D H Russell, M K Haddox
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Jan 1, 1972·Advances in Enzyme Regulation·H G Williams-AshmanA Schenone
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·M TakigawaF Suzuki

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