Hormonal activity of combinations of genistein, bisphenol A and 17beta-estradiol in the female Wistar rat

Archives of Toxicology
Simone SchmidtPatrick Diel

Abstract

Phytoestrogens have been described as weak estrogens, selective estrogen receptor mediators (SERMs) or to exhibit antiestrogenic properties. However, information about their activity in combination with xenoestrogens and 17beta-estradiol in vivo, is limited. Therefore, the combinatory activity of the phytoestrogen genistein (Gen), the industrial chemical bisphenol A (BPA), and ethinylestradiol (EE) in ovariectomized Wistar rats was analyzed in this study. All compounds were administered orally on three consecutive days (EE at 30 microg, Gen at 100 mg and BPA at 200 mg per kg body weight per day). The pure antiestrogen fulvestrant (3 mg/kg) served as estrogen receptor (ER) antagonist control. Effects on uterine wet weight, height of the uterine epithelium, uterine clusterin (Clu) and complement C3 expression, and the height of the vaginal epithelium were examined. Treatment with Gen alone resulted in a moderate stimulation of uterine weight; in the vagina the height of the epithelium was strongly stimulated. BPA did not stimulate any of the above-mentioned parameters significantly. In combination with EE, Gen acted on most of the analyzed parameters in an additive manner, whereas BPA significantly antagonized the effects of EE o...Continue Reading

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Citations

Nov 22, 2011·Archives of Toxicology·H M Bolt, J D Stewart
Jul 3, 2010·Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan·Sadahiro KawazoeTakashi Suzuki
Apr 10, 2013·International Journal of Medical Sciences·Naguib SallehSoh Onn Yeong
Oct 12, 2014·The Journal of Steroid Biochemistry and Molecular Biology·Annekathrin Martina KeilerOliver Zierau
Jan 22, 2011·Journal of Enzyme Inhibition and Medicinal Chemistry·Maya Haj HassanYves Combarnous
Oct 8, 2009·The Journal of Steroid Biochemistry and Molecular Biology·Anja PapkeGünter Vollmer
Apr 12, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Luísa CamachoK Barry Delclos
Jun 15, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Marjoke HeneweerAd Peijnenburg
May 8, 2016·Clinical Science·Margaret A ZimmermanSarah H Lindsey
Apr 11, 2018·Archives of Toxicology·Christopher J BorgertStephen P Baker
Apr 7, 2010·The Journal of Steroid Biochemistry and Molecular Biology·S ChennaiahC Suresh

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