Hormonal and body composition predictors of soluble leptin receptor, leptin, and free leptin index in adolescent girls with anorexia nervosa and controls and relation to insulin sensitivity.

The Journal of Clinical Endocrinology and Metabolism
Madhusmita MisraAnne Klibanski

Abstract

Anorexia nervosa (AN) is associated with very low levels of leptin, a cytokine secreted by adipose tissue and known to suppress appetite. Leptin may play a permissive role in onset of puberty and in resumption of gonadal function in conditions of undernutrition. The soluble leptin receptor (sOB-R) is the main leptin binding protein, and the ratio of serum leptin to sOB-R provides a measure of the free leptin index (FLI), which may be a more accurate determinant of leptin function. Determinants of sOB-R and FLI have not been examined in an adolescent population. We examined levels of sOB-R, leptin, and FLI, and body composition and hormonal determinants of these variables in 23 adolescent girls with AN and 21 healthy adolescent girls of comparable maturity prospectively over 1 yr. Measures of insulin resistance and adiponectin were also examined. We determined changes in levels of sOB-R, leptin, and FLI with weight recovery (defined as an increase in body mass index of >/=10%, n = 11), and with resumption of menstrual cycles (n = 13). Girls with AN had significantly higher levels of sOB-R (P = 0.0008) and significantly lower levels of leptin and FLI (P < 0.0001 for both) than healthy controls, and levels of FLI were reduced more...Continue Reading

References

Oct 1, 1994·The Journal of Pediatrics·N H GoldenI R Shenker
Jul 28, 1995·Science·M A PelleymounterF Collins
Jan 1, 1997·The Journal of Clinical Endocrinology and Metabolism·G A Laughlin, S S Yen
Feb 1, 1997·Endocrinology·C C CheungR A Steiner
Feb 1, 1997·The Journal of Clinical Investigation·R S AhimaJ S Flier
Jul 11, 1998·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·W KöppJ Hebebrand
Dec 19, 1998·Molecular Psychiatry·L AudiA Carrascosa
Jan 23, 1999·European Journal of Endocrinology·A ElimamC Marcus
Apr 24, 1999·Annals of Internal Medicine·C S Mantzoros
Jul 27, 1999·Metabolism: Clinical and Experimental·B L Grégoire NyombaL J Murphy
May 15, 2001·Biochemical and Biophysical Research Communications·A LammertJ Kratzsch
Jul 10, 2001·The Journal of Clinical Endocrinology and Metabolism·M WabitschJ Hebebrand
Sep 11, 2001·The Journal of Clinical Endocrinology and Metabolism·C A LissettS M Shalet
Feb 12, 2002·The Journal of Clinical Endocrinology and Metabolism·Paolo MarzulloRon G Rosenfeld
Apr 5, 2002·The Journal of Clinical Endocrinology and Metabolism·Francois M H van DielenJan Willem M Greve
Aug 3, 2002·European Journal of Endocrinology·Amira Elimam, Claude Marcus
Sep 6, 2002·The Journal of Clinical Endocrinology and Metabolism·Leslie A SoykaAnne Klibanski
Oct 5, 2002·The Journal of Clinical Endocrinology and Metabolism·J KratzschW Kiess
Dec 20, 2002·Endocrine Research·Jarmila KrizovaMartin Haluzik
Jan 10, 2003·The Journal of Clinical Endocrinology and Metabolism·Virginie TolleBruno Estour
Jan 10, 2003·The Journal of Clinical Endocrinology and Metabolism·Richard S LegroTom Lloyd
Apr 8, 2003·The Journal of Clinical Endocrinology and Metabolism·Nicola PannacciulliGiovanni De Pergola
May 2, 2003·American Journal of Physiology. Endocrinology and Metabolism·Polyxeni KoutkiaSteven Grinspoon
Jun 7, 2003·The American Journal of Clinical Nutrition·Madhusmita MisraAnne Klibanski
Jul 5, 2003·The Journal of Clinical Endocrinology and Metabolism·David R MannV Daniel Castracane

❮ Previous
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Citations

Aug 10, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·D J HowgateE Tsapakis
May 8, 2009·European Journal of Nutrition·Julia EnglChristoph F Ebenbichler
Dec 25, 2009·European Child & Adolescent Psychiatry·Susann ScheragAnke Hinney
Sep 15, 2006·Reviews in Endocrine & Metabolic Disorders·Madhusmita Misra, Anne Klibanski
Oct 25, 2006·Molecular Psychiatry·J HebebrandB Herpertz-Dahlmann
Jun 15, 2011·Journal of Child and Adolescent Psychopharmacology·Ingemar Swenne, Agneta Rosling
Nov 4, 2005·Biology of Reproduction·Michael C Henson, V Daniel Castracane
Sep 22, 2007·Current Opinion in Obstetrics & Gynecology·Neville H Golden
Aug 16, 2012·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Sarah E Gairdner, Catherine E Amara
Nov 8, 2011·Neuroendocrinology·Elena ValassiMadhusmita Misra
Mar 22, 2006·Pediatric Research·Madhusmita MisraAnne Klibanski
Jan 10, 2006·Journal of Pediatric Endocrinology & Metabolism : JPEM·M T Muñoz-Calvo
Aug 10, 2011·Journal of Pediatric Endocrinology & Metabolism : JPEM·Rafael M MantovaniAna Cristina Simões e Silva
Jan 1, 2014·Eating and Weight Disorders : EWD·Rami Bou Khalil, Charline El Hachem
Jul 25, 2014·The Journal of Endocrinology·Sharon H Chou, Christos Mantzoros
Jan 25, 2011·Journal of Neural Transmission·M FöckerJ Hebebrand
Apr 27, 2007·Nihon rinsho. Japanese journal of clinical medicine·Ken Ebihara
Aug 8, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L MaïmounC Sultan
Dec 12, 2012·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·G A Martos-MorenoJ Argente
Dec 23, 2009·Molecular and Cellular Endocrinology·G A Martos-MorenoJ Argente
Jul 28, 2009·Medicina clínica·María Luisa Fernández SotoMariela Varsavsky
Oct 18, 2008·Journal of Psychiatric Research·René Klinkby StøvingJan Frystyk
Nov 19, 2008·Child and Adolescent Psychiatric Clinics of North America·Timo D MüllerJohannes Hebebrand
Dec 13, 2006·Metabolism: Clinical and Experimental·Christina Nogueira AragãoCarmen Cabanelas Pazos-Moura
Sep 23, 2008·Clinical Endocrinology·Ayse Kubat UzumNese Colak Ozbey
Feb 28, 2009·The International Journal of Eating Disorders·Wendy Meyer SterlingStanley M Hertz
Dec 7, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Lei-Sheng JiangLi-Yang Dai
Jan 15, 2008·BJOG : an International Journal of Obstetrics and Gynaecology·Y JayasingheM Zacharin
Jun 25, 2008·Annals of the New York Academy of Sciences·Neville H Golden, Jennifer L Carlson
Sep 16, 2010·Annals of the New York Academy of Sciences·Efthimios DeligeoroglouG Creatsas
Sep 13, 2016·Adipocyte·Erica L SchellerWilliam P Cawthorn
Jan 1, 2006·Clinical Pediatric Endocrinology : Case Reports and Clinical Investigations : Official Journal of the Japanese Society for Pediatric Endocrinology·Iosif Kelesidis, Christos S Mantzoros
Oct 13, 2012·Psychoneuroendocrinology·Martine DuclosJan Pieter Konsman
Jun 28, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Irina KowalskaMarek Strączkowski
Mar 10, 2005·American Journal of Physiology. Endocrinology and Metabolism·Madhusmita MisraAnne Klibanski
Jan 26, 2008·Pediatric Pulmonology·Samya Z Nasr, Donna Drury
Apr 7, 2005·American Journal of Physiology. Endocrinology and Metabolism·Madhusmita MisraAnne Klibanski
Oct 29, 2008·Journal of Pediatric Gastroenterology and Nutrition·Junji TakayaKazunari Kaneko

❮ Previous
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