Hormonal and developmental regulation of DAX-1 expression in Sertoli cells

Molecular Endocrinology
K T TamaiPaolo Sassone-Corsi

Abstract

Mutations in the human DAX-1 gene lead to X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism. DAX-1 has been proposed to play a role in steroidogenesis because it is highly expressed in adrenocortical and testicular Leydig cells and because loss-of-function mutations lead to low serum levels of steroid hormones. Recent reports of DAX-1 expression in hypothalamus and pituitary, however, suggest additional functions for this protein. Here we demonstrate that DAX-1 is expressed in Sertoli cells of rat testis. This expression is regulated during spermatogenesis and peaks during the androgen-sensitive phase of the spermatogenic cycle. In addition, we show that DAX-1 expression in Sertoli cells is regulated developmentally. Maximum levels are present in the rat between postnatal days 20 and 30, during the first spermatogenic wave. Moreover, we show that activation of the cAMP-signaling pathway by the pituitary hormone FSH leads to a potent down-regulation of DAX-1 expression in cultured Sertoli cells. This down-regulation requires transcription and de novo protein synthesis. Taken together, these data indicate that DAX-1 expression in Sertoli cells may influence the development of spermatogenic cells in response ...Continue Reading

Citations

Sep 27, 2006·Proceedings of the National Academy of Sciences of the United States of America·Françoise DantzerJosiane Ménissier-de Murcia
May 30, 2002·Proceedings of the National Academy of Sciences of the United States of America·Sylvia G LehmannPaolo Sassone-Corsi
Jun 10, 2000·Molecular and Cellular Biology·E LalliP Sassone-Corsi
Apr 9, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·P J O'ShaughnessyP J Baker
Jul 3, 2015·Endocrine Journal·Tetsuya MizutaniKaoru Miyamoto
Oct 2, 2008·Endocrine Journal·Yasuhiro NakamuraHironobu Sasano
Apr 27, 2017·Molecular Biology and Evolution·Andrea PozziMarco Passamonti

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