Hormonal and metabolic effects of morning or evening dosing of the dipeptidyl peptidase IV inhibitor vildagliptin in patients with type 2 diabetes.

British Journal of Clinical Pharmacology
Yan-Ling HeWilliam P Dole

Abstract

Vildagliptin is an orally active, potent inhibitor of dipeptidyl peptidase IV and was developed for the treatment of type 2 diabetes. In clinical trials, once or twice daily dosing with vildagliptin (up to 100 mg day(-1)) has been shown to reduce endogenous glucose production and fasting plasma glucose in patients with type 2 diabetes. The comparative efficacy of vildagliptin under a morning vs. evening dosing regimen has not previously been determined. Once daily dosing with vildagliptin 100 mg for 28 days improved glycaemic control in patients with type 2 diabetes independent of whether vildagliptin was administered in the morning or evening. Morning or evening dosing with vildagliptin had similar effects on 24 h glycaemic control and plasma concentrations of the hormones insulin, glucagon and glucagon-like peptide 1. This randomized, double-blind, crossover study compared post-prandial hormonal and metabolic effects of vildagliptin, (an oral, potent, selective inhibitor of dipeptidyl peptidase IV [DPP-4]) administered morning or evening in patients with type 2 diabetes. Forty-eight patients were randomized to once daily vildagliptin 100 mg administered before breakfast or before dinner for 28 days then crossed over to the ot...Continue Reading

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Apr 20, 2007·Journal of Clinical Pharmacology·Yan-Ling HeJames E Foley
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Apr 11, 2008·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·V FonsecaS Dejager

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Citations

Jan 19, 2013·International Journal of Clinical Pharmacy·Gagandeep KaurBandana Saini
Nov 11, 2011·Clinical Therapeutics·Kathleen R RichardJulienne K Kirk
Jun 13, 2012·Clinical Pharmacokinetics·Larry K GolightlyMichael T McDermott
Oct 8, 2020·Clinical Pharmacology and Therapeutics·James C WaltonRandy J Nelson
Jan 9, 2018·Mayo Clinic Proceedings·Sofie HædersdalTina Vilsbøll

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