Hormonal and osmotic regulation of NaCl transport in renal distal nephron epithelium

The Japanese Journal of Physiology
Yoshinori Marunaka

Abstract

One of the most important factors controlling blood pressure is the total body Na+ content, which depends upon Na+ intake and excretion. The kidney influences body Na+ content by regulating the tubular absorption of the Na+ filtered through the glomeruli. Thus, the regulation of Na+ absorption in the tubules of the kidney plays an important role in controlling blood pressure. More than 99% of the Na+ passing through the glomerulus is reabsorbed in the kidney. About 90% of the filtered Na+ through the glomerulus is reabsorbed in the proximal tubule and the ascending limb of the loop of Henle. The remainder of the Na+ absorption occurs in the distal nephron. This process is regulated by hormones such as aldosterone and antidiuretic hormone (ADH), and also by the osmolality of the plasma. These observations suggest that the regulation of Na+ transport in the distal nephron by hormones and osmolality plays an important role in the control of blood pressure. The distal nephron is composed of two different types of epithelial cells: the principal cell and the intercalated cell. The latter is also composed of two types of cells: alpha and beta intercalated cells. In addition to Na+ absorption, the distal-nephron epithelial cells also ...Continue Reading

Citations

Jun 10, 2008·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Makoto TakadaShigeru Hokari
Jan 12, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Akiyuki Taruno, Yoshinori Marunaka
Sep 21, 2001·The Japanese Journal of Physiology·Y Tsuchiya, Y Suzuki
May 8, 2009·Biomedical Research·Masahiro MakiToshikazu Kubo
Mar 7, 2014·Respiratory Physiology & Neurobiology·Yoshinori Marunaka
Jan 25, 2013·Molecular & Cellular Proteomics : MCP·Tianfu WuChandra Mohan
Sep 4, 2007·Biochemical and Biophysical Research Communications·Makoto YasudaYoshinori Marunaka
Mar 21, 2007·General and Comparative Endocrinology·Makoto Takada, Shigeru Hokari
Jul 31, 2007·Biochemical and Biophysical Research Communications·Naomi NiisatoYoshinori Marunaka
Oct 27, 2011·Journal of Biomedicine & Biotechnology·Yoshinori MarunakaTakahiro Kubota
Sep 20, 2016·Biochemical and Biophysical Research Communications·Ken-Ichi Nakajima, Yoshinori Marunaka
Jun 3, 2017·Annals of the New York Academy of Sciences·Yoshinori Marunaka
Jan 15, 2018·The Journal of Physiological Sciences : JPS·Yukiko IkeuchiYoshinori Marunaka
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