Hormonal and subjective responses to intravenous meta-chlorophenylpiperazine in bulimia nervosa

Archives of General Psychiatry
R D LevitanG M Brown

Abstract

Several lines of evidence point to serotonergic abnormalities in patients with bulimia nervosa (BN). Our goal was to further examine central serotonergic function in bulimic patients using neuroendocrine and subjective responses to the postsynaptic serotonin receptor agonist meta-chlorophenylpiperazine (mCPP). Using a double-blind, randomized, placebo-controlled design, we assessed neuroendocrine and subjective responses to intravenous mCPP (0.1 mg/kg) and placebo in 16 patients with BN, free of medication, and 14 normal control subjects. Plasma prolactin and cortisol levels were used as neuroendocrine measures, whereas subjective responses were measured using a visual analog scale of 10 different mood states. Compared with controls, the BN group exhibited blunted prolactin and net cortisol responses following mCPP challenge. Subjective responses, while preliminary, also differed between groups on items related to anxiety, calmness, and altered self-awareness. Evidence of dysfunction at or downstream of central serotonergic receptors in BN confirms and extends findings of prior research.

Citations

Jan 7, 2000·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·O SpigsetT Mjöndal
Oct 12, 1999·Journal of the American Academy of Child and Adolescent Psychiatry·K M ThompsonJ E Mitchell
Jul 27, 2001·Psychiatry Research·H SteigerS N Young
Feb 9, 2000·Biological Psychiatry·W H KayeT E Weltzin
Jun 7, 2000·Psychoneuroendocrinology·F G MoellerA C Swann
Jul 28, 2004·International Review of Psychiatry·D A Klein, B T Walsh
Jul 7, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Kenneth R BruceSimon N Young
Jan 24, 2007·Biological Psychiatry·Ursula F BailerWalter H Kaye
Jul 31, 1999·Comprehensive Psychiatry·R D LevitanM A Katzman
Jan 25, 2008·Accident; Analysis and Prevention·Sophie CoutureRené Carbonneau
May 26, 2004·Physiology & Behavior·Diane Alix Klein, B Timothy Walsh
Jul 24, 2014·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Bogdan GaluscaBruno Estour
Jun 10, 2005·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·R D LevitanJ L Kennedy
Jan 13, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Howard SteigerJulie Hakim
Apr 21, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Howard SteigerAnne Marie Parent
May 1, 2012·Journal of Clinical Psychopharmacology·Erin N UmbergDavid J Greenblatt
Mar 18, 2019·Psychiatry Research·Magnus SjögrenJitka Stilund Hansen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.