PMID: 187930Dec 10, 1976

Hormonal control of fat cells adenylate cyclase

Molecular and Cellular Biochemistry
R H Harris, A Bennun


Fat cells were preincubated for 2 h in the presence and absence of growth hormone (GH) and Dexamethasone (Dex) before the addition of increasing concentrations of either epinephrine, theophylline or glucagon and final incubation of the cells for an additional 5 minutes. GH and Dex increased by 85%, 28% and 72%, respectively, the cAMP levels reached in the sole presence of 10(-5)M epinephrine, 10(-2)M theophylline or 5 X 10(-5)M glucagon. An adenylate cyclase particulate preparation shows that epinephrine decreases Km from 2mM to 0.6 MM and increases Vmax and the strength of interaction value (n) from 0.91 to 1.75.


Jan 1, 1975·Biochemical Society Transactions·S Brydon-Golz, A Bennun
Sep 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·A G Gilman
Nov 15, 1973·Molecular and Cellular Biochemistry·V A Najjar, A Constantopoulos
Mar 1, 1959·The Journal of Clinical Investigation·M S RABEN, C H HOLLENBERG
Nov 1, 1964·Archives of Biochemistry and Biophysics·A O STOPPANIE M DEPAHN
Oct 23, 1964·Biochimica Et Biophysica Acta·A O STOPPANID E PAHNEM

Related Concepts

Cyclic AMP, (R)-Isomer
Adenylate Cyclase
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