PMID: 6106901Oct 9, 1980Paper

Hormonal control of neurotransmitter choice in sympathetic neurone cultures

Nature
K Fukada

Abstract

Manipulation of the cellular and hormonal environment of cultures of dissociated primary neurones can be used to explore a neurone's developmental potential and to investigate the factors required for normal development. For example, developing adrenergic sympathetic neurones can be influenced to become cholinergic by both diffusible and membrane-bound factors from certain types of non-neuronal cells; when medium conditioned by incubation on heart cell cultures (CM) is placed on the neurones, they develop the ability to produce acetylcholine (ACh) and they form functional cholinergic synapses with each other. Hormones could also contribute to the control of this transmitter choice, and McLennan et al. recently reported that corticosterone treatment of whole superior cervical ganglia (SCG) greatly inhibited the cholinergic development of these ganglia in culture. It was not clear, however, whether the hormone acted directly on the neurones or indirectly via the non-neuronal cells. To study the role of hormones on this transmitter choice, I have now developed a serum-free medium (based on that of Sato and co-workers) for the preparation of conditioned medium. The results obtained with this system show that glucocorticoids and epi...Continue Reading

References

Jan 1, 1978·Annual Review of Neuroscience·P H Patterson
Jan 1, 1979·Methods in Enzymology·E Hawrot, P H Patterson
Jan 1, 1979·Methods in Enzymology·J BottensteinR Wu
Jun 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·W L McKeehanR G Ham

❮ Previous
Next ❯

Citations

Jul 1, 1991·Journal of Neuroscience Research·R P HartG M Jonakait
Jan 1, 1988·European Journal of Applied Physiology and Occupational Physiology·M Cabanac, H Brinnel
Dec 1, 1986·Cellular and Molecular Neurobiology·R L PapkeR E Oswald
Jan 1, 1984·Pharmacology & Therapeutics·G A Buznikov
May 20, 1991·Brain Research. Developmental Brain Research·J E García-Arrarás
Oct 21, 1991·Brain Research. Developmental Brain Research·K FukadaM F Towle
Oct 1, 1993·Trends in Neurosciences·G M Jonakait
Apr 1, 1988·Molecular and Cellular Endocrinology·C A Barnett, E L Pritchett
Jan 22, 1990·Molecular and Cellular Endocrinology·S E RundleJ W Funder
Jan 1, 1985·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Marta C RomanoBeatriz Fuentes-Pardo
May 25, 2004·Neuroscience Research·Yuichiro WatanabeHiroyuki Nawa
Oct 13, 2001·Brain Research. Molecular Brain Research·G VilluendasL Cacicedo
May 14, 2011·Lab on a Chip·Akimasa TakeuchiYasuhiko Jimbo
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·K Fukada
Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·T Yamamori
Apr 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M Freidin, J A Kessler
Dec 1, 1993·The Journal of Cell Biology·K DjabaliC G Dotti
Apr 1, 1993·Reviews in the Neurosciences·R Barker, S Dunnett
Jun 1, 1983·Brain Research·D G Puro

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
K Fukada
Proceedings of the National Academy of Sciences of the United States of America
J E Adler, I B Black
Proceedings of the National Academy of Sciences of the United States of America
P A WalickeP H Patterson
© 2021 Meta ULC. All rights reserved