Hormonal cryptorchidism therapy: systematic review with metanalysis of randomized clinical trials

Pediatric Surgery International
Márcia Riromi HennaBernardo Garcia de Oliveira Soares

Abstract

The importance of cryptorchidism treatment concerns the possibility of diminishing risk of malignant degeneration and improving fertility. Success rates of hormonal treatment vary: 0-55% with human chorionic gonadotropin (hCG) and 9-78% with gonadotropin-releasing hormone (GnRH). Due to uncertainties regarding the effectiveness of this treatment, a systematic review and meta-analysis of randomized controlled trials (RCTs) on hormonal cryptorchidism treatment was done using the methodology of Cochrane Collaboration. Two studies compared hCG with GnRH, with a testicular descent rate of 25% vs. 18%, respectively. Nine trials compared intranasal LHRH with placebo, with complete testicular descent rates of 19% vs. 5%. Two other studies comparing doses and administration intervals could not be pooled together due to heterogeneity. With the information analyzed until the present, the evidence for the use of hCG vs. GnRH shows advantages for hCG, and this review also shows that there is evidence that luteinizing hormone releasing hormone (LHRH) is more effective than placebo. But because this evidence is based on few trials, with small sample sizes and moderated risk of bias, this treatment cannot be recommended for everyone, and there...Continue Reading

Citations

Apr 14, 2007·Pediatric Surgery International·Feilim MurphyPrem Puri
Jun 21, 2005·Cell and Tissue Research·Marko Kaleva, Jorma Toppari
Jan 12, 2012·BMC Pediatrics·Federico MarchettiUNKNOWN Italian Study Group on Undescended Testes
May 3, 2014·Annales d'endocrinologie·Jorma ToppariHelena E Virtanen
Aug 27, 2014·Clinics in Perinatology·Lauren BaldingerAseem R Shukla
Mar 14, 2008·International Journal of Andrology·L RichiardiO Akre
Apr 28, 2007·Acta Paediatrica·Arni V ThorssonMartin Ritzén
Mar 1, 2007·Acta Paediatrica·E Martin RitzénH Virtanen
Jun 24, 2010·The Urologic Clinics of North America·Richard A AshleyThomas F Kolon
Jul 8, 2008·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Faruk Hadziselimovic
Sep 10, 2014·Urologia·Paolo Caione, Roberto Tambucci
Jul 24, 2008·European Journal of Endocrinology·Ieuan A Hughes, Carlo L Acerini
Aug 30, 2008·European Journal of Endocrinology·E Martin Ritzén
Apr 14, 2016·Pediatric Surgery International·Jeremy WongJohn M Hutson
Apr 6, 2012·Current Opinion in Endocrinology, Diabetes, and Obesity·S Faisal Ahmed, Stuart O'Toole
Feb 20, 2020·Der Urologe. Ausg. A·R SteinB Ludwikowski
Apr 11, 2020·Der Urologe. Ausg. A·R SteinN Younsi
May 15, 2013·Endocrine Reviews·John M HutsonNan Chen
Feb 6, 2020·Frontiers in Endocrinology·Wiwat RodprasertJorma Toppari
Jul 22, 2009·Journal of Pediatric Endocrinology & Metabolism : JPEM·Ozgur PirgonCihan Meral
Jul 6, 2016·International Journal of Pediatric Endocrinology·Anne-Sophie Lambert, Pierre Bougneres
Apr 23, 2020·Frontiers in Endocrinology·Carla Bizzarri, Marco Cappa
May 10, 2016·Current Treatment Options in Pediatrics·David Kurz
Oct 18, 2014·Deutsches Ärzteblatt International·Georg HrivatakisVerena Ellerkamp

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