Hormonal determinants of the severity of andropausal and depressive symptoms in middle-aged and elderly men with prediabetes

Clinical Interventions in Aging
Michał RabijewskiPaweł Piątkiewicz

Abstract

Andropausal and depressive symptoms are common in aging males and may be associated with hormone deficiency. We investigated the severity of andropausal and depressive symptoms, as well as their hormonal determinants, in 196 middle-aged and elderly men (age range: 40-80 years) with prediabetes (PD) and in 184 healthy peers. PD was diagnosed according to the definition of the American Diabetes Association. The severity of andropausal and depressive symptoms was assessed using the Aging Males' Symptoms Rating Scale and the Self-Rating Depression Scale. Total testosterone (TT), calculated free testosterone (cFT), dehydroepiandrosterone sulfate (DHEAS), and insulin-like growth factor 1 (IGF-1) were measured. The prevalence of andropausal syndrome in men with PD was significantly higher than that in healthy men (35% vs 11%, respectively). In men with PD aged 40-59 years, the severity of sexual, psychological, and all andropausal symptoms was greater than in healthy peers, while in elderly men (60-80 years), only the severity of psychological symptoms was greater than in healthy peers. The severity of depressive symptoms in the middle-aged men with PD was greater than in healthy peers, while the severity of depressive symptoms in eld...Continue Reading

Citations

Jun 10, 2017·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Michał RabijewskiPaweł Piątkiewicz
Apr 1, 2018·International Journal of Geriatric Psychiatry·Meijuan XiaoJincai He
Dec 4, 2019·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Maliheh AbootalebiFarnoosh Azizi

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BETA
androgen replacement therapy

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STATISTICA

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