[Hormonal dysnatremia].

Annales d'endocrinologie
P Karaca, R Desailloud

Abstract

Because of antidiuretic hormone (ADH) disorder on production or function we can observe dysnatremia. In the absence of production by posterior pituitary, central diabetes insipidus (DI) occurs with hypernatremia. There are hereditary autosomal dominant, autosomal recessive or X- linked forms. When ADH is secreted but there is an alteration on his receptor AVPR2, it is a nephrogenic diabetes insipidus in acquired or hereditary form. We can make difference on AVP levels and/or on desmopressine response which is negative in nephrogenic forms. Hyponatremia occurs when there is an excess of ADH production: it is a euvolemic hypoosmolar hyponatremia. The most frequent etiology is SIADH (syndrome of inappropriate secretion of ADH), a diagnostic of exclusion which is made after eliminating corticotropin deficiency and hypothyroidism. In case of brain injury the differential diagnosis of cerebral salt wasting (CSW) syndrome has to be discussed, because its treatment is perfusion of isotonic saline whereas in SIADH, the treatment consists in administration of hypertonic saline if hyponatremia is acute and/or severe. If not, fluid restriction demeclocycline or vaptans (antagonists of V2 receptors) can be used in some European countries. F...Continue Reading

References

Jan 1, 1980·Annual Review of Medicine·R ZerbeG Robertson
May 29, 2000·The New England Journal of Medicine·H J Adrogué, N E Madias
Dec 23, 2003·Best Practice & Research. Clinical Endocrinology & Metabolism·Joseph G Verbalis
Aug 5, 2005·The New England Journal of Medicine·Alan Segal
Mar 7, 2006·Postgraduate Medical Journal·M S B HudaG Gill
May 5, 2006·Kidney International·A Greenberg, J G Verbalis
Jul 18, 2006·The American Journal of Medicine·Gary L Robertson
Nov 22, 2007·The American Journal of Medicine·Joseph G VerbalisRichard H Sterns
Nov 6, 2008·The Journal of Clinical Endocrinology and Metabolism·Wiebke FenskeBruno Allolio
Nov 3, 2009·NDT Plus·Robert ZietseEwout J Hoorn
Jan 9, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Sinead KinsellaJoseph A Eustace
Feb 10, 2010·Archives of Internal Medicine·Ron WaldNicolaos E Madias
Oct 16, 2010·Critical Care : the Official Journal of the Critical Care Forum·Guy DecauxAlain Soupart
Nov 29, 2011·Annales d'endocrinologie·Marie-Christine VantyghemClaire Douillard
Jun 4, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ruediger W LehrichArthur Greenberg

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Related Papers

Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
Paravee HiranratSumarlee Srivuthana
Chinese Journal of Traumatology = Zhonghua Chuang Shang Za Zhi
Jia-ning CaiJun Yi
The New England Journal of Medicine
Brian J FeldmanStephen E Gitelman
© 2021 Meta ULC. All rights reserved