Hormonal exposures and breast cancer in a sample of women with systemic lupus erythematosus

Rheumatology
S BernatskyC Gordon

Abstract

To determine if breast cancer risk in women with SLE is modified by a history of exposure to hormone replacement therapy (HRT) or oral contraceptives (OC), after adjusting for other risk factors. Data were pooled from SLE cohorts at three centres. For each female cohort member (n = 871), the probability of developing breast cancer was estimated from factors (age, parity, age at first live birth, age of menarche, personal history of benign breast disease, family history) in the Gail model, an established tool for predicting breast cancer risk. From these probabilities, the expected number of breast cancers for the cohort was estimated. Actual occurrence of cases was determined by linkage with regional cancer registries. Standardized incidence ratios (SIRs; ratio of cancers observed to expected) were calculated, with subgroup analyses according to HRT and OC exposure. In the cohort, 15 breast cancers occurred vs 7.2 predicted [SIR 2.1, 95% confidence interval (CI) 1.1, 3.5]. When controlling for Gail model risk factors, estimates were similar for women never exposed to HRT vs those exposed to HRT. Adjusted SIR estimates appeared similar also for women exposed or not exposed to OC. Although not definitive, the data suggest that th...Continue Reading

Citations

Sep 7, 2006·Journal of the National Cancer Institute·William E BarlowKarla Kerlikowske
Jul 26, 2012·Rheumatology·Carl Turesson, Eric L Matteson
Jul 23, 2009·Obstetrics and Gynecology·Kelly R CulwellMaria del Carmen Cravioto
Nov 24, 2005·Current Rheumatology Reports·Sasha BernatskyAnn E Clarke
Aug 1, 2009·Autoimmunity Reviews·Emese KissPeter Szodoray
Jan 12, 2008·The Breast Journal·Michalis Kontos, Ian S Fentiman
Feb 6, 2017·La Revue de médecine interne·N GensousP Duffau
Apr 28, 2009·Lupus·M GayedC Gordon
May 28, 2013·Asia-Pacific Journal of Public Health·Thunyarat AnothaisintaweeAmmarin Thakkinstian
May 10, 2005·Arthritis and Rheumatism·S BernatskyA Clarke

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