Hormonal profile during the follicular phase in cycles stimulated with a combination of human menopausal gonadotrophin and gonadotrophin-releasing hormone antagonist (Cetrorelix)

Human Reproduction
C AlbanoP Devroey

Abstract

A third generation gonadotrophin-releasing hormone antagonist (Cetrorelix) was used during ovarian stimulation in 32 patients undergoing assisted reproduction, in order to prevent the premature luteinizing hormone (LH) surge. In all patients, ovarian stimulation was carried out with two or three ampoules of human menopausal gonadotrophin (HMG), starting on day 2 of the menstrual cycle. In addition, 0.5 mg of Cetrorelix was administered daily from day 6 of HMG treatment until the day of ovulation induction by human chorionic gonadotrophin (HCG). A significant drop in plasma LH concentration was observed within a few hours of the first administration of Cetrorelix (P < 0.005). Moreover, no LH surge was detected at any point in the treatment period in any of the 32 patients. A mean oestradiol concentration of 2111 +/- 935 ng/l was observed on the day of the HCG administration, indicating normal folliculogenesis. Like LH, progesterone concentration also dropped within a few hours of the first administration of Cetrorelix (P < 0.005). A 0.5 mg daily dose of Cetrorelix prevented a premature LH surge in all the 32 patients treated.

Citations

Jul 14, 2001·European Journal of Obstetrics, Gynecology, and Reproductive Biology·N NikolettosK Diedrich
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Jan 1, 2008·Journal of Human Reproductive Sciences·Kamath MsGeorge K
Jun 21, 2006·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Nicola DoldiAugusto Ferrari
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Jul 13, 2007·Human Reproduction Update·H M FatemiP Devroey
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