PMID: 2121395Aug 1, 1990Paper

Hormonal profiles following clomiphene citrate therapy in conception and nonconception cycles

Clinical Endocrinology
Z ShohamC Pariente

Abstract

The hormonal profiles following clomiphene citrate (CC) administration during a single cycle were compared in infertile women who conceived and in those who did not. Of 41 treated patients, ovulation was assumed to have occurred in 28 and was confirmed by clinical pregnancy in five. In the 28 women who presumably ovulated, two distinct patterns of hormonal secretion were observed. A normal response was exhibited by 17 patients (including the five who became pregnant). The other 11 patients exhibited an abnormal response, characterized by significantly higher luteinizing hormone (LH)/follicle-stimulating hormone (FSH) ratios than in the normal response group from day 9 until the occurrence of the LH peak (days 9 and 10, P less than 0.05; days 11 and 12, P less than 0.001), and significantly higher oestradiol (E2) levels throughout the cycle (P less than 0.01). In addition, in comparison with the normal response group their LH levels during the follicular phase were significantly higher (P less than 0.05) but their LH peaks at ovulation were significantly lower (P less than 0.02). Moreover, their progesterone levels, in contrast to those in the normal response group, began to increase prior to the LH peak and remained high during...Continue Reading

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Citations

Jul 1, 1993·European Journal of Obstetrics, Gynecology, and Reproductive Biology·D MeirowJ G Schenker
Jan 16, 1995·The American Journal of Medicine·M Gibson
Apr 25, 2000·Molecular and Cellular Endocrinology·C M Howles
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Jun 14, 2008·Reproductive Biomedicine Online·Ahmed BadawyMohamed Abulatta

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