PMID: 109329Feb 1, 1979

Hormonal regulation in two rat mammary cancer cell lines: glucocorticoid and androgen receptors

Molecular and Cellular Endocrinology
F VignonH Rochefort

Abstract

We have studied the hormonal control of two continuous cell lines derived from rat-mammary tumors induced by two different carcinogens (dimethylbenzanthracene and N-nitrosomethylurea). The steroid receptors were assayed using charcoal or hydroxyapatite and the effect of different hormones on cell growth was evaluated by measuring total DNA and following the growth of transplanted cells in nude mice. Similar results were found for the two cell lines; they were unresponsive to estrogen since they did not contain appreciable amounts of estradiol receptor. Conversely, these two cell lines contained high concentrations of androgen and glucocorticoid receptors, which were both transferable to the nucleus. While dexamethasone stimulated, directly or indirectly, the growth of RBA and NMU cells, the effect of androgens on cell growth is still questioned. These two cell lines offer a potential model to study the mechanism of action of androgens and glucocorticoids in mammary cancer.

References

Feb 1, 1976·Experimental Cell Research·I Jung-TestasE E Baulieu
Apr 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J B BakerD D Cunningham
Apr 1, 1978·Molecular and Cellular Endocrinology·M PfahlS Bourgeois
Jan 1, 1976·Annual Review of Biochemistry·D Gospodarowicz, J S Moran
Jan 1, 1972·Annual Review of Biochemistry·E V Jensen, E R DeSombre

Related Concepts

Carcinoma, Cribriform
Cytoplasmic Matrix
Oradexon
Estradiol, (16 alpha,17 beta)-Isomer
Estrenes
Hydrocortisone, (9 beta,10 alpha,11 alpha)-Isomer
Mammary Neoplasms, Experimental
NSC-23909
Progesterone, (9 beta,10 alpha)-Isomer
Androgen Receptor

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