PMID: 8973379Sep 1, 1996Paper

Hormonal regulation of cardiac cystic fibrosis transmembrane conductance regulator chloride channels

Japanese Heart Journal
M HorieS Sasayama

Abstract

The chloride conductance that arises from the stimulation of beta-adrenoceptors has been shown to be carried by a cardiac isoform of cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channels. This brief review will focus first upon the cellular signal transduction system for the activation of this type of Cl- channels and then its regulation by catecholamines, muscarinic agonists, endothelin-1 and angiotensin-II. Both in physiological and pathological conditions, the complex interaction of these agonists modulates the Cl- conductance, which is potentially arrhythmogenic by shortening the action potential duration and inducing the depolarization.

Citations

Jan 1, 1997·Progress in Biophysics and Molecular Biology·B NiliusG Droogmans
Feb 1, 2003·Acta Physiologica Scandinavica·B Nilius, G Droogmans
Jan 10, 2003·American Journal of Physiology. Cell Physiology·Kenneth R HallowsJ Kevin Foskett

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