Hormonal regulation of expression of growth differentiation factor-9 receptor type I and II genes in the bovine ovarian follicle

Reproduction : the Official Journal of the Society for the Study of Fertility
Barana C JayawardanaAkio Miyamoto

Abstract

Growth differentiation factor-9 (GDF-9) and bone morphogenetic proteins (BMPs) are crucial factors in follicular growth and development. GDF-9 and BMPs initiate signaling by assembling type I (ALK-3, ALK-5 and ALK-6) and type II (BMPRII) receptors. However, the mechanism regulating the expression of these receptors in the process of bovine follicle development is still unknown. The aim of the present study was to clarify the involvement of receptor systems for GDF-9 and BMPs in follicular selection by examining the effects of FSH and estradiol-17beta (E2) on the regulation of BMPRII, ALK-3, ALK-5 and ALK-6 mRNA expression in bovine granulosa cells (GCs). To observe mRNA expression during follicular development, follicles were obtained from heifers and classified into two groups: pre-selection follicles (PRFs) (an average of 7.7 mm follicles with low E2) and post-selection follicles (POFs) (an average of 15 mm follicles with high E2). Theca layer cells (TCs) and GCs were harvested from aspirated follicles. For in vitro studies, GCs were obtained from bovine follicles of 4-7 mm diameter and cultured in Dulbecco's modified Eagle's/F12 (DMEM/F-12) medium with 10% fetal calf serum for 24 h. The medium was then replaced with serum-fr...Continue Reading

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Citations

Sep 22, 2010·Journal of Molecular Histology·R Z SunZ H Liu
Nov 13, 2010·Molecular and Cellular Biochemistry·Hiromichi YamashitaTakashi Shimizu
Mar 25, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Xiaofeng ZhengPaul D Carrière
Apr 11, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Francois ParadisGeorge R Foxcroft
Jul 6, 2014·Theriogenology·Miho Makita, Takashi Miyano
May 23, 2012·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·A-Qin ChenXiang-Jun Leng
Jan 29, 2011·The Journal of Steroid Biochemistry and Molecular Biology·C BeckerH H D Meyer
Oct 2, 2020·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Ali FalahatiP Mark Lokman

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