PMID: 9437234Jan 23, 1998Paper

Hormonal replacement therapy affects calcitonin gene-related peptide and atrial natriuretic peptide secretion in postmenopausal women

European Journal of Endocrinology
A SpinettiA R Genazzani

Abstract

Menopause is associated with critical changes in the cardiovascular system, and the possible effect of hormonal replacement therapy (HRT) on these changes is under investigation. The aim of our study was to evaluate in postmenopausal women the effects of HRT and clonidine on the response of plasma calcitonin gene-related peptide (CGRP) and plasma atrial natriuretic peptide (ANP) to the upright posture test and the saline infusion test respectively. CGRP and ANP levels were measured with specific radioimmunological assays and expressed in pmol/l (means +/- S.E.M). Postmenopausal women (age 46-53 years) (n = 18) were studied before and after 3 months of HRT (n = 13) or clonidine treatment (n = 5). After HRT or clonidine treatment plasma CGRP levels (14.9 +/- 1.6 and 15.9 +/- 3.8 pmol/l) were significantly higher than before (9.8 +/- 0.6 and 10.5 +/- 1.6 pmol/l) (P < 0.01). The assumption of upright posture caused no change in plasma CGRP levels before treatment, while after HRT, but not after clonidine treatment, an increase in plasma CGRP levels was observed (P < 0.01 at 5 and 20 min). Basal plasma ANP levels significantly decreased after both HRT and clonidine treatment (P < 0.01). In untreated women the saline infusion test di...Continue Reading

Citations

Mar 24, 2004·Maturitas·Anna H KarjalainenY Antero Kesäniemi
Jul 20, 2002·Trends in Endocrinology and Metabolism : TEM·Chandrasekhar YallampalliSunil J Wimalawansa
Jun 9, 2005·Gynecologic and Obstetric Investigation·Anna-Clara E SpetzMats L Hammar
Jan 1, 2010·Journal of Mid-life Health·Sudhaa SharmaVishal R Tandon
Jul 16, 2014·Climacteric : the Journal of the International Menopause Society·G CasanovaP M Spritzer
Mar 23, 2010·Experimental Neurology·Susan Sarajari, Monica M Oblinger
Oct 31, 2006·Pharmacology & Therapeutics·Saurabh GuptaAntoinette MaassenVanDenBrink
Jun 3, 2011·Headache·Saurabh GuptaNancy E J Berman
Apr 6, 2017·Climacteric : the Journal of the International Menopause Society·D W SturdeeM A Lumsden
Jun 15, 2007·Annals of Medicine·Richard W TroughtonM Gary Nicholls
Oct 12, 2018·Endocrine·Maria Alice OliveiraValéria Ernestânia Chaves

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