Hormonal responses to d- and d,l-fenfluramine in healthy human subjects

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
E F CoccaroR Hauger

Abstract

Two different doses of d-fenfluramine HCl and d,l-fenfluramine HCl (0.5 mg/kg and 1.0 mg/kg) were administered to 11 healthy male volunteers to compare the neuroendocrine responses to these two forms of fenfluramine in human subjects. Prolactin (PRL) responses to d- and d,l-fenfluramine were significantly greater than those to placebo and were equivalent at both dose levels. Adrenocortiatrophic-releasing hormone (ACTH) and cortisol (CORT) responses to d-fenfluramine at both dose levels were also significantly greater than those to placebo. In contrast, the higher dose of d,l-fenfluramine was associated only with a significant CORT response in comparison to placebo. PRL responses to d-fenfluramine were higher than the PRL response to d,l-fenfluramine at either dose level. The PRL response to d-fenfluramine at 0.5 mg/kg was very highly correlated with the PRL responses to d,l-fenfluramine at 1.0 mg/kg (r = 0.97, n = 10). Homovanillic acid (HVA) were not altered by either d, or d,l-fenfluramine at either dose in a subsample of subjects (n = 4). ACTH/CORT responses to d- and d,l-fenfluramine were modestly intercorrelated. These data suggest that the PRL response evoked by d-fenfluramine is quantitatively very similar to that evoked...Continue Reading

Citations

Apr 12, 2008·Pituitary·Alberto Giacinto AmbrogioFrancesco Cavagnini
Apr 20, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·David J BrunswickJay D Amsterdam
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Sep 30, 1999·Life Sciences·D K Raap, L D Van de Kar
Mar 26, 2002·Psychoneuroendocrinology·Kurt P SchulzJeffrey M Halperin
Sep 25, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Emil F CoccaroRichard J Kavoussi
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