PMID: 4339974Jul 29, 1972Paper

Hormonal responses to synthetic luteinizing hormone and follicle stimulating hormone-releasing hormone in man

British Medical Journal
G M BesserW P Collins

Abstract

The effects of the gonadotrophin-releasing hormone, synthetic decapeptide luteinizing hormone/follicle stimulating hormone-releasing hormone (LH/FSH-RH), have been studied in 18 normal men and five women in the follicular phase of their menstrual cycle. Rapid and dose-dependent (25 to 100 mug) increases in serum immunoreactive LH were seen, which reached a peak 20 to 30 minutes after a rapid intravenous injection. Similar but much smaller increases in serum immunoreactive FSH were seen. These conclusions have been validated by using two different immunoassay systems for each hormone. The LH/FSH-RH therefore causes both LH and FSH release in man as in animals but does not affect growth hormone, thyrotrophin, or ACTH. The gonadotrophin responses were the same in the women as in the men but were insufficient in the men to cause statistically significant changes in the serum levels of the gonadal steroid hormones, testosterone or oestradiol, or in their precursors 17 alpha-hydroxyprogesterone or progesterone. In the women, however, there was a rise in oestradiol after the 100-mug doses. The use of LH/FSH-RH will provide an important test to define the level of the lesion in hypogonadal patients and also should be valuable in the tr...Continue Reading

References

Jul 3, 1971·Lancet·B J OrmstonR Hall
Jan 8, 1971·Biochemical and Biophysical Research Communications·W F WhiteT W Redding
Apr 16, 1971·Biochemical and Biophysical Research Communications·A V SchallyL Debeljuk
Jun 18, 1971·Biochemical and Biophysical Research Communications·H MatsuoA V Schally
Nov 1, 1964·Transactions of the New York Academy of Sciences·S M MCCANN, A P DHARIWAL

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Citations

Apr 12, 2008·Pituitary·Andrea M IsidoriAndrea Lenzi
Feb 1, 1976·Australian and New Zealand Journal of Medicine·S J Judd, L Lazarus
Mar 1, 1974·Journal of Clinical Pathology·G M Besser, C H Mortimer
Jan 1, 1976·Journal of Clinical Pathology. Supplement (Association of Clinical Pathologists)·C H Mortimer, T Yeo
Feb 1, 1975·Postgraduate Medical Journal·M ShahmaneshM Hartog
Aug 12, 2006·Journal of Occupational Medicine and Toxicology·Mohamed A Dalvie, Jonathan E Myers
Aug 1, 1975·Journal of Neurosurgery·J M CoenegrachtG Padberg
Nov 1, 1974·Clinics in Endocrinology and Metabolism·C R Edwards, G M Besser
Mar 1, 1977·Clinics in Endocrinology and Metabolism·C H Mortimer
Nov 1, 1983·Clinics in Endocrinology and Metabolism·P E Belchetz
Jul 29, 2008·Peptides·C N JayasenaS R Bloom
Apr 28, 2011·Clinical Endocrinology·Ammar WakilStephen L Atkin
Aug 1, 1976·Metabolism: Clinical and Experimental·F WollesenW D Odell
Jul 3, 1971·Lancet·B J OrmstonR Hall
Nov 1, 1973·Clinics in Endocrinology and Metabolism·W R KeyeR B Jaffe
Jan 13, 2017·European Journal of Endocrinology·A Kirstine BangNiels Jørgensen
May 1, 1979·The Australian & New Zealand Journal of Obstetrics & Gynaecology·I M HoldawayJ T France
Sep 1, 1979·Clinical Endocrinology·H H GohS S Ratnam
Jan 1, 1979·Clinical Endocrinology·I FettesR Volpé
Sep 1, 1975·Clinical Endocrinology·A Gomez-PanA J Kastin
Feb 1, 1978·Clinical Endocrinology·W D Odell, R S Swerdloff
Aug 1, 1974·The Journal of Obstetrics and Gynaecology of the British Commonwealth·R W ShawJ C Marshall
Oct 1, 1974·The Journal of Obstetrics and Gynaecology of the British Commonwealth·M Katz, P J Carr
Jan 1, 1973·The Journal of Obstetrics and Gynaecology of the British Commonwealth·P J Keller
Apr 1, 1975·British Journal of Obstetrics and Gynaecology·A M JequierH S Jacobs
Sep 1, 1976·The British Journal of Addiction to Alcohol and Other Drugs·J W WrightV Marks
Feb 1, 1994·Clinical Endocrinology·E Jódar-GimenoF Escobar-Jiménez
Dec 1, 1985·Journal of Endocrinological Investigation·F FraioliM Dufau
Feb 1, 1987·Postgraduate Medicine·M R McNally

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