PMID: 4339974Jul 29, 1972Paper

Hormonal responses to synthetic luteinizing hormone and follicle stimulating hormone-releasing hormone in man

British Medical Journal
G M BesserW P Collins


The effects of the gonadotrophin-releasing hormone, synthetic decapeptide luteinizing hormone/follicle stimulating hormone-releasing hormone (LH/FSH-RH), have been studied in 18 normal men and five women in the follicular phase of their menstrual cycle. Rapid and dose-dependent (25 to 100 mug) increases in serum immunoreactive LH were seen, which reached a peak 20 to 30 minutes after a rapid intravenous injection. Similar but much smaller increases in serum immunoreactive FSH were seen. These conclusions have been validated by using two different immunoassay systems for each hormone. The LH/FSH-RH therefore causes both LH and FSH release in man as in animals but does not affect growth hormone, thyrotrophin, or ACTH. The gonadotrophin responses were the same in the women as in the men but were insufficient in the men to cause statistically significant changes in the serum levels of the gonadal steroid hormones, testosterone or oestradiol, or in their precursors 17 alpha-hydroxyprogesterone or progesterone. In the women, however, there was a rise in oestradiol after the 100-mug doses. The use of LH/FSH-RH will provide an important test to define the level of the lesion in hypogonadal patients and also should be valuable in the tr...Continue Reading


Jul 3, 1971·Lancet·B J OrmstonR Hall
Jan 8, 1971·Biochemical and Biophysical Research Communications·W F WhiteT W Redding
Apr 16, 1971·Biochemical and Biophysical Research Communications·A V SchallyL Debeljuk
Jun 18, 1971·Biochemical and Biophysical Research Communications·H MatsuoA V Schally
Nov 1, 1964·Transactions of the New York Academy of Sciences·S M MCCANN, A P DHARIWAL

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