Hormonal therapy for oestrogen receptor-negative breast cancer is associated with higher disease-specific mortality

Annals of Oncology : Official Journal of the European Society for Medical Oncology
A MerglenC Bouchardy

Abstract

Tamoxifen has a remarkable impact on the outcome of oestrogen receptor (ER)-positive breast cancer. Without proven benefits, tamoxifen is occasionally prescribed for women with ER-negative disease. This population-based study aims to estimate the impact of tamoxifen on the outcome of ER-negative disease. We identified all women (n = 528) diagnosed with ER-negative invasive breast cancer between 1995 and 2005. With Cox regression analysis, we calculated breast cancer mortality risks of patients treated with tamoxifen compared with those treated without tamoxifen. We adjusted these risks for the individual probabilities (propensity scores) of having received tamoxifen. Sixty-nine patients (13%) with ER-negative disease were treated with tamoxifen. Five-year disease-specific survival for women treated with versus without tamoxifen were 62% [95% confidence interval (CI) 48% to 76%] and 79% (95% CI 75% to 83%), respectively (P(Log-rank) < 0.001). For ER-negative patients, risk of death from breast cancer was significantly increased in those treated with tamoxifen compared with patients treated without tamoxifen (adjusted hazard ratio = 1.7, 95% CI 1.1-2.9, P = 0.031). Our results show that patients with ER-negative breast cancer tre...Continue Reading

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Citations

Apr 15, 2011·Journal of Veterinary Internal Medicine·S Guil-LunaJ Martín de Las Mulas
Jul 6, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Chafika MazouniPierre-Marie Martin
Jun 19, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Sara AlknerUNKNOWN South Swedish and South-East Swedish Breast Cancer Groups
May 23, 2012·The Journal of Obstetrics and Gynaecology Research·Tomohito TanakaMasahide Ohmichi

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