PMID: 11907928Mar 23, 2002Paper

Hormonal treatment and psychological function during the menopausal transition: an evaluation of the effects of conjugated estrogens/cyclic medroxyprogesterone acetate

Climacteric : the Journal of the International Menopause Society
S K KhooB Raphael

Abstract

To investigate the effect of hormone treatment on psychosocial distress of women during the menopausal transition (aged 40-52 years, still menstruating and with minor symptoms), in a study carefully designed to reduce bias and placebo effect. The study was randomized, controlled by placebo, blinded to the subject, investigators and biostatistician, crossed-over after 6 months, and evaluated by a 77-item questionnaire every month for 12 months. The medication tested was continuous conjugated estrogens (Premarin) and cyclic medroxyprogesterone acetate (Provera). Of an eligible 105 apparently healthy women, recruited by advertisement, 83 completed the questionnaires for the study. Randomization was successful. While there was a substantial variation over time in the change of scores for all the psychosocial outcomes, there was no significant difference between active and placebo treatment when order of treatment allocation was ignored. However, a strong and consistent effect of the order of treatment allocation for many of the scores was found; in particular, the effect of active treatment was substantially stronger when it was administered second. Positive effects of active treatment were found for the score for the overall sympt...Continue Reading

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Citations

Sep 12, 2002·Pharmacotherapy·Adriane Fugh-Berman, Cynthia Pearson
Jan 23, 2014·Menopause : the Journal of the North American Menopause Society·Claudio N Soares
Apr 14, 2010·The Psychiatric Clinics of North America·Claudio N Soares, Benicio N Frey
Sep 6, 2005·Brain Research Bulletin·Marjolein GerritsGert J Ter Horst
Jul 2, 2015·Depression and Anxiety·David R RubinowBradley Gaynes
Aug 11, 2019·Ecological Applications : a Publication of the Ecological Society of America·Vernon C Bleich
Aug 28, 2004·CNS Drugs·Fokko J BoskerJakob Korf

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