Nov 1, 1983

Hormone binding in brain tumors

R P GlickE M Fors


Brain tumors from 64 patients were studied for the presence of hormone binding. Estradiol binding was detected in 34 patients: 13 of 21 meningiomas, 4 of 8 schwannomas, 1 oligodendroglioma, 1 of 5 benign gliomas, 4 of 5 malignant gliomas, 5 of 11 metastatic tumors, and 6 of 11 pediatric tumors: 1 medulloblastoma, 2 malignant ependymomas, 1 benign astrocytoma, 1 malignant sarcoma, and 1 malignant teratoma. Eleven patients were studied for progesterone binding, which was measurable in 7: 1 schwannoma, 3 meningiomas, 1 malignant sarcoma (pediatric group), 1 astrocytoma--gemistocytic (pediatric group), and 1 metastatic adenocarcinoma. There were 41 females and 23 males in the study. Fifteen females were premenopausal, 18 were postmenopausal, and 8 were in the pediatric group. Of the 34 tumors with measurable estradiol binding, 23 occurred in females. In the progesterone group, 4 of the 7 tumors with measurable binding activity were from female patients. In the pediatric group, estradiol binding was detected in 1 medulloblastoma, 2 malignant ependymomas, 1 malignant teratoma, 1 malignant sarcoma, and 1 astrocytoma. Five of the 6 pediatric tumors with estradiol binding were malignant, and both pediatric tumors with progesterone bindi...Continue Reading

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Mentioned in this Paper

Anaplastic Ependymoma
Dermatofibrosarcoma Protuberans
Protein Binding
Progesterone, (9 beta,10 alpha)-Isomer
Premenopausal Symptoms
Melanotic Medulloblastoma
Mixed Oligoastrocytoma
Spinal Meningioma

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