PMID: 2151368Nov 1, 1990Paper

Hormone dependence of a mouse mammary tumor line induced in vivo by medroxyprogesterone acetate

Breast Cancer Research and Treatment
E KordonC Dosne Pasqualini

Abstract

The administration of MPA to virgin female BALB/c mice led to the development of mammary adenocarcinomas, which in further in vivo transplants gave rise to both MPA-dependent and MPA-independent lines. In this paper we chose one of the MPA-dependent lines with high contents of estrogen (ER) and progesterone (PR) receptors, and were able to demonstrate that a) the growth of these tumors could be manipulated by the administration or the withdrawal of the hormonal supply; b) PR were down-regulated in MPA-treated mice; c) progesterone had the same stimulatory effect as MPA on tumor growth; d) tumors did not grow in estrogen-treated mice; e) tumor growth was much lower in males than in females; f) the presence of the ovaries had a positive influence on tumor growth, even in the presence of MPA; g) the withdrawal of progestin pellets in ovariectomized mice usually led to complete remissions followed by regrowth of the tumors after several weeks; and h) the regrowing tumors maintained their steroid receptor pattern and (in 3 out of 4 cases) their hormone-dependent behavior in further passages.

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Citations

Jul 29, 2008·Journal of Mammary Gland Biology and Neoplasia·Edith C Kordon
Apr 24, 1999·The Journal of Steroid Biochemistry and Molecular Biology·M F MontecchiaC Lanari
Oct 2, 2002·Breast Cancer Research and Treatment·Valeria BuggianoEdith C Kordon
Jun 5, 2003·Breast Cancer Research and Treatment·Caroline A LambClaudia Lanari
Feb 6, 2004·Breast Cancer Research and Treatment·Alejo EfeyanAlfredo A Molinolo
Feb 22, 2012·Endocrine-related Cancer·Claudia LanariAlfredo A Molinolo
Dec 7, 2005·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Rodney BaberMichelle Kwik
Dec 2, 1991·International Journal of Cancer. Journal International Du Cancer·E KordonC Dosne Pasqualini
Sep 29, 2011·Molecular and Cellular Endocrinology·Sunshine Daddario Axlund, Carol A Sartorius
Jun 2, 2021·Essays in Biochemistry·Sebastian GiulianelliClaudia Lanari

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