Hormone ontogeny in the ovine fetus: XIX: The effect of a potent luteinizing hormone-releasing factor agonist on gonadotropin and testosterone release in the fetus and neonate

Pediatric Research
S J ClarkM M Grumbach

Abstract

To investigate further the role of the hypothalamic luteinizing hormone releasing factor (LRF) pulse generator and the pituitary LRF receptor in the regulation of gonadotropin secretion and gonadal steroidogenesis in the ovine (O) fetus and neonatal lamb, we measured the increment (the difference between the concentration of plasma LH at time 0 and peak LH) in oLH (delta oLH) and oFSH (delta oFSH) responses to a potent LRF agonist, D-Trp6Pro9NEt-LRF (LRF-A), after consecutive daily doses in 17 ovine fetuses (six females, 11 males) and in 15 neonatal lambs (six females, nine males). Seven of the lambs had been studied as fetuses. In addition, plasma concentrations of testosterone (T) and androstenedione (delta 4A) were measured in nine male fetuses. After a stimulatory response to the first dose of LRF-A, the mean delta oLH and delta oFSH responses in the 106- to 118-d gestation fetuses of both sexes were significantly suppressed by the fourth dose and in the neonatal lamb by the second dose. Suppression was sustained throughout the duration of LRF-A therapy which included the gestational interval when the fetal pituitary exhibits its greatest responsiveness to an acute dose of synthetic LRF. The duration of oLH and oFSH suppres...Continue Reading

Citations

Jan 29, 1999·Endocrinology and Metabolism Clinics of North America·F J HayesW F Crowley
Aug 21, 2002·American Journal of Respiratory and Critical Care Medicine·UNKNOWN American Thoracic Society/European Respiratory Society
Apr 29, 2015·Frontiers in Neuroendocrinology·Tony M Plant
Mar 1, 1992·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J E RobillardP A Jose
Jul 1, 1990·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J E RobillardP A Jose
Mar 1, 1996·Archives of Disease in Childhood. Fetal and Neonatal Edition·J A BirdM E Symonds

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