PMID: 8470946Mar 1, 1993Paper

Hormone profiles and contralateral testicular histology in Down's syndrome with unilateral testicular tumor

Archives of Andrology
I SasagawaM Tomaru

Abstract

Hormonal profiles and testicular histology were studied in two patients with Down's syndrome with unilateral testicular tumor. Plasma levels of LH and FSH were elevated above normal ranges in both cases. In case 1, plasma testosterone level was abnormally low, but prolactin level in plasma was within the normal range. Case 2 showed elevated concentration of plasma prolactin and normal level of plasma testosterone. The administration of LH-RH resulted in low response of plasma gonadotropins. The response of plasma testosterone to the administration of HCG was abnormally suppressed in both cases. Testicular histology showed reduction of Johnsen score count and tubular diameter, and an increase in wall thickness. These results indicated that male patients with Down's syndrome have an abnormality in hypothalamo-pituitary-gonadal axis.

References

Jul 1, 1978·Acta Endocrinologica·R F HoranH H Bode
Jan 1, 1989·Urologia Internationalis·I SasagawaT Katayama
Jun 1, 1987·American Journal of Medical Genetics·Y H HsiangA C Warren
Apr 1, 1982·Journal of Medical Genetics·W A CampbellW H Price
Jan 1, 1983·Human Genetics·R JohannissonE Schwinger
Jan 1, 1980·Hormone Research·J HasenL R Shapiro

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Citations

Jan 26, 2016·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Manuel NistalMiguel Reyes-Múgica
Nov 27, 1999·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·N AngelopoulouK Mandroukas
Oct 27, 2010·International Journal of Urology : Official Journal of the Japanese Urological Association·Kuri SuzukiNobuhisa Ishii
Oct 18, 2014·Orthodontics & Craniofacial Research·M Korayem, E AlKofide

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