Hormone receptor expression in craniopharyngiomas: a clinicopathological correlation

Neurosurgery
Bernd M HofmannRolf Buslei

Abstract

Extensive neurosurgical resection of craniopharyngiomas often requires lifetime hormonal substitution. We investigated the effect of the hormone receptor expression of insulinlike growth factor-1, growth hormone-releasing hormone receptor, growth hormone, progesterone, estrogen (ER-1, ER-beta), and leptins (Ra6.4, Ra12.1, Rb) on tumor recurrence, size, and proliferation using clinical, histopathological, and molecular genetic analysis. cDNA expression analysis was obtained in a cohort of 20 patients suffering from a craniopharyngioma to systematically determine the expression of above-mentioned receptors. In addition, 51 tumor samples were available to immunohistochemically investigate the extent and distribution of estrogen and progesterone receptors. In 18 tumor specimens, both experimental paradigms could be performed. All hormone receptors under study, including leptins, were detectable in craniopharyngiomas with reverse-transcription polymerase chain reaction but did not reach significance regarding the tested parameters. However, a correlation was observed between tumor size and cell proliferation indexes, as well as with cDNA expression levels of ER-1 and growth hormone receptors. The present preliminary data point to a ...Continue Reading

References

Jan 1, 1992·Journal of Neurosurgery·H J HoffmanS I Blaser
Jul 1, 1990·Journal of Neurosurgery·T E AdamsonM G Yaşargil
Oct 7, 1998·Journal of Neurosurgery·G R BuninJ M Bruner
Feb 9, 1999·Journal of Neurosurgery·R FahlbuschM Buchfelder
Feb 9, 1999·Journal of Neurosurgery·J HoneggerR Fahlbusch
Feb 26, 2000·Neurosurgery·J DuffB W Scheithauer
Nov 10, 2001·The Journal of Clinical Endocrinology and Metabolism·G FrajeseJ P Monson
Jan 15, 2002·Pituitary·I TsumanumaR V Lloyd
Feb 5, 2002·Pituitary·M Sone, R Y Osamura
Feb 5, 2002·Pituitary·V PopovicF F Casanueva
May 1, 2002·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Dau-Ming NiuTai-Tong Wong
Nov 7, 2002·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Richard Hayward
Apr 14, 2004·Developmental Medicine and Child Neurology·Andrea PorettiEugen Boltshauser
Apr 24, 2004·Clinical Endocrinology·Lene R ClausenJens O L Jørgensen
Jul 8, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Elfar UlfarssonLeonard Girnita
Dec 31, 2005·Journal of Neurosurgery·Tatsuya KobayashiToshinori Hasegawa
Jan 20, 2006·Acta Neuropathologica·Rolf BusleiIngmar Blümcke
May 3, 2006·Clinical Endocrinology·Niki KaravitakiJohn A H Wass
Jul 11, 2006·Ultrastructural Pathology·Lucio AgozzinoLuigi Cuccurullo
Sep 20, 2006·Acta Paediatrica·Feyza Darendeliler On Behalf Of The Kigs International Board

❮ Previous
Next ❯

Citations

Feb 5, 2013·Endocrine·Federica GuaraldiSilvia Grottoli
Nov 3, 2012·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Qiang LiJianguo Xu
Dec 19, 2012·International Journal of Radiation Oncology, Biology, Physics·Thomas E MerchantFrederick A Boop
Feb 9, 2020·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Elżbieta MoszczyńskaMieczysław Szalecki

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.

© 2021 Meta ULC. All rights reserved