PMID: 2819666Dec 15, 1989

Hormone receptor status in human endometrial adenocarcinoma

Cancer
F De Cicco NardoneS Dell'Acqua

Abstract

Steroid receptor levels were determined in 196 samples of endometrial adenocarcinoma: cytosol estradiol receptors (ERc) were measured in 171 samples, cytosol progesterone receptors (PRc) in all samples; nuclear estradiol receptors (ERn) and nuclear progesterone receptors (PRn) in 68 samples; total estradiol receptors (ERt = ERc plus ERn) and total progesterone receptors (PRt = PRc plus PRn) were measured in 68 samples. The ERc levels were 88.2 +/- 8.9 (mean +/- SEM) and ERn were 94.4 +/- 15.6 fmol/mg protein; PRc levels were 197.9 +/- 25.9 and PRn 178.3 +/- 55.9 fmol/mg protein. The ERt levels were 162.6 +/- 23.2 and PRt 249.8 +/- 75.7 fmol/mg protein. The presence of PRc was related to the ERc levels according to the cut-off used. Estradiol receptors (ER) and progesterone receptors (PR) were present in the cytoplasmic and nuclear fractions in 60.2% and 36.8% of cases, respectively. The simultaneous presence of both ERt and PRt was observed only in 27.9% of cases. In the normal endometrium ERc and PRc were negatively correlated (r = -0.525, P less than 0.005), whereas in endometrial adenocarcinoma the correlation was positive (r = 0.491, P less than 0.001). In contrast with the normal endometrium the correlation between ERc and...Continue Reading

References

Jan 1, 1976·Annual Review of Physiology·J Gorski, F Gannon
Mar 15, 1978·Biochemical and Biophysical Research Communications·H ErikssonJ H Clark
Apr 1, 1988·American Journal of Obstetrics and Gynecology·C E EhrlichW M Alford
Apr 1, 1985·American Journal of Obstetrics and Gynecology·W T CreasmanD L Clarke-Pearson
Jul 1, 1974·The Journal of Endocrinology·S G CrockerR J King
Jan 1, 1980·Journal of Steroid Biochemistry·H Fleming, E Gurpide

Citations

Apr 1, 1997·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·W R Miller, S P Langdon
Dec 23, 2009·Brazilian Oral Research·Fabio Augusto ItoMárcio Ajudarte Lopes

Related Concepts

Carcinoma, Cribriform
Cell Nucleus
Cytoplasmic Matrix
Estradiol Receptors
Receptors, Progesterone
Uterine Cancer

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