PMID: 11336881May 5, 2001Paper

Hormone replacement reduces elevated in vivo venous tone in hypertensive ovariectomized rats

Journal of the Society for Gynecologic Investigation
Szabolcs VárbíróBéla Székács

Abstract

The venous system may play a role in the development and progression of postmenopausal hypertension. In the present study, we investigated the effect of chronic angiotensin II-induced hypertension on the geometric, elastic, and contractile properties of the saphenous vein in sex hormone deficient and replaced female rats. Thirty Sprague-Dawley rats were ovariectomized (n = 10), ovariectomized and angiotensin-infused (n = 10), or ovariectomized plus angiotensin-infused and hormone replaced with estradiol and medroxyprogesterone (n= 10). After 4 weeks, the saphenous veins were removed and cylindrical segments of the vessels were placed into a microangiograph and cannulated at both ends. Intraluminal pressure versus outer diameter curves were registered in Krebs-Ringer solution, in maximal norepinephrine contraction, and in full papaverine relaxation. In vivo venous tone of the saphenous vein in ovariectomized plus angiotensin-infused animals was significantly higher than in ovariectomized animals without angiotensin treatment (27.2 +/- 3.7% versus 5.3 +/- 2.1%, respectively; P <.05). Hormone replacement restored venous tone (9.6 +/- 3.4%; P <.01). In vitro pressure-induced myogenic tone was markedly reduced by chronic angiotensin...Continue Reading

Citations

Feb 17, 2007·Clinical Endocrinology·Nina S Stachenfeld, Hugh S Taylor
Jul 19, 2008·American Journal of Hypertension·Douglas S MartinKathleen M Eyster
Mar 5, 2002·Menopause : the Journal of the North American Menopause Society·Szabolcs VárbíróBéla Székacs
Mar 18, 2010·Acta Physiologica Hungarica·M MatraiSzabolcs Várbíró

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