Hormone replacement therapy after menopause and risk of breast cancer in BRCA1 mutation carriers: a case-control study

Breast Cancer Research and Treatment
Joanne KotsopoulosSteven A Narod

Abstract

Many BRCA1 mutation carriers undergo elective surgical oophorectomy (often before menopause) to manage their elevated risk of developing ovarian cancer. It is important to clarify whether or not the use of hormone replacement therapy (HRT) to mitigate the symptoms associated with surgical or natural menopause is safe in women with an inherited BRCA1 mutation and no personal history of breast or ovarian cancer. We conducted a case-control analysis of 432 matched pairs of women with a BRCA1 mutation. Detailed information on HRT use after menopause (duration, type, age at first/last use, formulation) was obtained from a research questionnaire administered at the time of study enrollment. Conditional logistic regression was used to estimate the odds ratio (OR) and 95 % confidence intervals (CI) associated with HRT use. The mean duration of HRT use after menopause was 4.3 years among the cases and 4.4 years among the controls (P = 0.83). The adjusted OR for breast cancer comparing all women who ever used HRT to those who never used HRT was 0.80 (95 % CI 0.55-1.16; P = 0.24). Findings did not differ by type of menopause (natural vs. surgical), by recency of use, by duration of use, and by formulation type. These findings suggest that...Continue Reading

References

Jul 19, 2002·JAMA : the Journal of the American Medical Association·Jacques E RossouwUNKNOWN Writing Group for the Women's Health Initiative Investigators
Aug 21, 2003·Lancet·Valerie Beral, UNKNOWN Million Women Study Collaborators
Jul 29, 2005·Cancer Causes & Control : CCC·Joanne KotsopoulosSteven A Narod
Sep 20, 2005·Breast Cancer Research : BCR·Joanne KotsopoulosSteven A Narod
Oct 13, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Timothy R RebbeckUNKNOWN PROSE Study Group
Nov 4, 2006·The Lancet Oncology·Gillian K ReevesUNKNOWN Million Women Study Collaborators
Nov 23, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christina A ClarkeLisa J Herrinton
Nov 14, 2007·Journal of Clinical Epidemiology·S KroppD Flesch-Janys
Jan 16, 2008·International Journal of Cancer. Journal International Du Cancer·Kelly A MetcalfeUNKNOWN Hereditary Breast Cancer Clinical Study Group
Apr 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·Kathryn B HorwitzCarol A Sartorius
Jul 24, 2008·The Journal of Clinical Endocrinology and Metabolism·Kathryn B Horwitz, Carol A Sartorius
Sep 25, 2008·Journal of the National Cancer Institute·Andrea EisenUNKNOWN Hereditary Breast Cancer Clinical Study Group
May 21, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Christie R EhemanMary C White
May 7, 2010·Nature·Purna A JoshiRama Khokha
Dec 15, 2010·Breast Cancer Research : BCR·Joanne KotsopoulosBernard A Rosner
Feb 1, 2011·Journal of the National Cancer Institute·Valerie BeralUNKNOWN Million Women Study Collaborators
Aug 3, 2011·Nature Reviews. Clinical Oncology·Steven A Narod
Dec 7, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Nasim MavaddatUNKNOWN Consortium of Investigators of Modifiers of BRCA1/2
Apr 2, 2013·Journal of the National Cancer Institute·Rowan T ChlebowskiRoss L Prentice
Oct 22, 2013·The Lancet Oncology·Martin WidschwendterIan J Jacobs
Jan 25, 2014·Breast Cancer Research and Treatment·Joanne KotsopoulosUNKNOWN Hereditary Breast Cancer Clinical Study Group
Feb 26, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Amy P M FinchSteven A Narod
Mar 20, 2015·Journal of the National Cancer Institute·B A M Heemskerk-GerritsenUNKNOWN Hereditary Breast and Ovarian Cancer Research Group Netherlands
Jun 23, 2015·Stem Cell Reports·Purna A JoshiRama Khokha

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Citations

Oct 19, 2017·Familial Cancer·Stephanie KeartonJo Burke
May 2, 2018·JAMA Oncology·Joanne KotsopoulosUNKNOWN Hereditary Breast Cancer Clinical Study Group
Aug 25, 2018·The Cochrane Database of Systematic Reviews·George U ElejeOnyinye O Okonkwo
Sep 4, 2017·Environmental Health : a Global Access Science Source·Janet M GrayJeanne Rizzo
Sep 8, 2016·Journal of the National Cancer Institute·Joanne KotsopoulosUNKNOWN Hereditary Breast Cancer Clinical Study Group
Mar 25, 2019·Climacteric : the Journal of the International Menopause Society·R F M VermeulenM van Beurden
Jun 2, 2016·American Society of Clinical Oncology Educational Book·Mary E Sabatini, Leif W Ellisen
Sep 29, 2017·Clinical Obstetrics and Gynecology·Sarah M TemkinLori Minasian
Mar 14, 2020·Obstetrics and Gynecology·Sheryl A KingsbergJames H Liu
May 28, 2020·Hormone Molecular Biology and Clinical Investigation·Laura SabianiGilles Houvenaeghel
Aug 18, 2020·BJOG : an International Journal of Obstetrics and Gynaecology·F GabaR Manchanda
Apr 1, 2018·The Journal of Obstetrics and Gynaecology Research·Isik KabanFugen Akar
Oct 27, 2016·Breast Cancer Research and Treatment·Joanne KotsopoulosSteven A Narod
Jul 28, 2018·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Lisa A RubinsakSarah M Temkin
Aug 17, 2020·Menopause : the Journal of the North American Menopause Society·Javier Mejia-GomezUNKNOWN and the Hereditary Breast Cancer Clinical Study Group
Mar 21, 2021·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Rachel Michaelson-CohenShani Paluch-Shimon
Apr 9, 2021·Obstetrics and Gynecology·Mariam M AlHilli, Holly J Pederson
Mar 21, 2020·Best Practice & Research. Clinical Obstetrics & Gynaecology·Faiza Gaba, Ranjit Manchanda
Nov 15, 2021·American Journal of Obstetrics and Gynecology·Nan HuoMichelle M Mielke

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