Hormone replacement therapy and breast cancer. A review of current knowledge

Drug Safety : an International Journal of Medical Toxicology and Drug Experience
L Bergkvist, I Persson

Abstract

More than 50 studies looking at the relationship between hormone replacement therapy and breast cancer have been published. Overall the results are reassuring. There is no evidence of an increased risk of breast cancer after ever use of exogenous estrogens. However, when long term use (i.e. use for more than 10 to 15 years) is considered the majority of data are compatible with a small increase in the risk, in the magnitude of 30 to 50%, possibly limited to women who are currently receiving hormone replacement therapy or who have recently stopped such therapy. This would translate into an increase in the absolute risk of developing breast cancer of 3 to 4% of among postmenopausal women in the Western world. No consistent evidence exists on differing risks of breast cancer with different types of estrogens, and no clear dose-relationship has been found. Risk estimates for combined estrogen-progestogen regimens have been of the same magnitude as for estrogens alone; thus, no clear evidence of a protective effect of the addition of a progestogen has been found. Investigations into a possible interaction between estrogen supplementation and other known risk factors for breast cancer have not yielded any consistent results. Cancers ...Continue Reading

Citations

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