Hormone replacement therapy and the prevention of postmenopausal osteoporosis

Przegla̜d menopauzalny = Menopause review
M Gambacciani, M Levancini

Abstract

Fracture prevention is one of the public health priorities worldwide. Estrogen deficiency is the major factor in the pathogenesis of postmenopausal osteoporosis, the most common metabolic bone disease. Different effective treatments for osteoporosis are available. Hormone replacement therapy (HRT) at different doses rapidly normalizes turnover, preserves bone mineral density (BMD) at all skeletal sites, leading to a significant, reduction in vertebral and non-vertebral fractures. Tibolone, a selective tissue estrogenic activity regulator (STEAR), is effective in the treatment of vasomotor symptoms, vaginal atrophy and prevention/treatment of osteoporosis with a clinical efficacy similar to that of conventional HRT. Selective estrogen receptor modulators (SERMs) such as raloxifene and bazedoxifene reduce turnover and maintain or increase vertebral and femoral BMD and reduce the risk of osteoporotic fractures. The combination of bazedoxifene and conjugated estrogens, defined as tissue selective estrogen complex (TSEC), is able to reduce climacteric symptoms, reduce bone turnover and preserve BMD. In conclusion, osteoporosis prevention can actually be considered as a major additional benefit in climacteric women who use HRT for tr...Continue Reading

Citations

Oct 27, 2017·Journal of Applied Oral Science : Revista FOB·Roberto HollandCarlos Estrela
Sep 21, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Yang SongJianhong Zhou
Apr 13, 2020·Clinical Oral Implants Research·Dragos ApostuHorea Rares Ciprian Benea
Aug 28, 2020·Journal of the Science of Food and Agriculture·Cheng-Liang XieDong H Lee
Oct 13, 2018·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·René Danilo VerboketLaurent Maximilian Willems
Jan 27, 2020·Journal of Bone and Mineral Metabolism·Hawley C AlmstedtJoseph W LaBrie
Jul 29, 2020·Frontiers in Endocrinology·Babak ArjmandBagher Larijani
Apr 25, 2018·Hormones & Cancer·Jesse A DorchakPaula A Witt-Enderby
Feb 16, 2021·Frontiers in Immunology·Rebecca ShepherdBoris Novakovic

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Methods Mentioned

BETA
X-ray
hormone replacement therapy

Software Mentioned

FRAX

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