Hormone-replacement therapy and the risk of breast cancer

CA: a Cancer Journal for Clinicians
B S Hulka

Abstract

At least 30 epidemiologic studies designed to identify an association between hormone-replacement therapy and breast cancer risk have been published since 1974. In general, the design, quality, and analytic strategies used in these studies have improved over the years, and the number of subjects in each study has increased. The results from studies published prior to 1985 can be summarized as showing a small increase in the risk of breast cancer after many years of estrogen use. Even this tentative conclusion is debatable, however, since many rigorous studies showed no association between estrogen use and breast cancer. This review will summarize the earlier findings and emphasize several large, recent studies that add at least two new dimensions to this body of research; they provide data from Europe and on the addition of progestins to the therapeutic regimen. This review indicates the following: 1. Analyses of ever versus never use of estrogen-replacement therapy show no association with breast cancer risk. 2. Duration of estrogen-replacement therapy affects risk. Based on studies in the United States, a relative risk of about 1.5 may be reached after 15 or more years of use. 3. The increase in risk after long-duration hormo...Continue Reading

Citations

Aug 27, 1992·The New England Journal of Medicine·B L Riggs, L J Melton
Apr 1, 1993·Journal of the American Geriatrics Society·G A Greendale, H L Judd
Jun 5, 1998·Annual Review of Public Health·E Barrett-Connor, D Grady
Aug 26, 1998·Journal of Cellular Biochemistry·M J Diaz-PerezI W Wainer
Aug 1, 1994·Cancer·B S HulkaR A Lininger
Jan 1, 1996·Acta Oncologica·K B HorwitzG S Takimoto
Nov 1, 1993·Breast Cancer Research and Treatment·V G VogelE Higginbotham
May 20, 2000·Annals of the New York Academy of Sciences·G N Koukoulis

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