Hormone replacement therapy, calcium and vitamin D3 versus calcium and vitamin D3 alone decreases markers of cartilage and bone metabolism in rheumatoid arthritis: a randomized controlled trial [ISRCTN46523456

Arthritis Research & Therapy
Helena Forsblad d'EliaHans Carlsten

Abstract

This study aimed to evaluate the effects of hormone replacement therapy (HRT), known to prevent osteoporosis and fractures, on markers of bone and cartilage metabolism. Furthermore, we assessed whether changes in these markers corresponded to alterations in bone mineral density and radiographic joint destructions in postmenopausal women with rheumatoid arthritis. Eighty-eight women were randomized to receive HRT, calcium, and vitamin D3, or calcium and vitamin D3 alone, for 2 years. Bone turnover was studied by analyzing serum levels of C-terminal telopeptide fragments of type I collagen (CTX-I), C-terminal telopeptide of type I collagen (ICTP), bone sialoprotein, and C-terminal propeptide of type I procollagen (PICP) and cartilage turnover by urinary levels of collagen type II C-telopeptide degradation fragments (CTX-II) and cartilage oligomeric matrix protein (COMP) in serum. Treatment with HRT resulted in decrease in CTX-I (P < 0.001), ICTP (P < 0.001), PICP (P < 0.05), COMP (P < 0.01), and CTX-II (P < 0.05) at 2 years. Reductions in CTX-I, ICTP, and PICP were associated with improved bone mineral density. Of the markers tested, CTX-I reflected bone turnover most sensitively; it was reduced by 53 +/- 6% in the patients recei...Continue Reading

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Citations

Nov 3, 2011·Nature Reviews. Rheumatology·Maria G Tektonidou, Michael M Ward
Dec 17, 2008·Women's Health·M GerosaP L Meroni
Nov 30, 2005·Immunological Reviews·Hans Carlsten
Jan 21, 2010·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Per QvistAnne-Christine Bay-Jensen
Jul 21, 2007·Endocrine Reviews·Rainer H Straub
Aug 5, 2009·Biomarker Insights·Susan TsengPaul E Di Cesare
Aug 6, 2010·Molecular and Cellular Endocrinology·Ulrika IslanderHans Carlsten

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Methods Mentioned

BETA
hysterectomy
ELISA
ESR

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