Hormone replacement therapy for women previously treated for endometrial cancer.

The Cochrane Database of Systematic Reviews
Katharine A EdeyMartha Hickey

Abstract

Endometrial cancer is the sixth most common cancer in women worldwide and most commonly occurs after the menopause (75%) (globocan.iarc.fr). About 319,000 new cases were diagnosed worldwide in 2012. Endometrial cancer is commonly considered as a potentially 'curable cancer,' as approximately 75% of cases are diagnosed before disease has spread outside the uterus (FIGO (International Federation of Gynecology and Obstetrics) stage I). The overall five-year survival for all stages is about 86%, and, if the cancer is confined to the uterus, the five-year survival rate may increase to 97%. The majority of women diagnosed with endometrial cancer have early-stage disease, leading to a good prognosis after hysterectomy and removal of the ovaries (oophorectomy), with or without radiotherapy. However, women may have early physiological and psychological postmenopausal changes, either pre-existing or as a result of oophorectomy, depending on age and menopausal status at the time of diagnosis. Lack of oestrogen can cause hot flushes, night sweats, genital tract atrophy and longer-term adverse effects, such as osteoporosis and cardiovascular disease. These changes may be temporarily managed by using oestrogens, in the form of hormone replac...Continue Reading

References

Mar 1, 1979·American Journal of Obstetrics and Gynecology·C B HammondR T Parker
Feb 1, 1983·Gynecologic Oncology·J V Bokhman
Mar 22, 1980·British Medical Journal·M E PatersonJ W Studd
Nov 1, 1996·American Journal of Obstetrics and Gynecology·J A ChapmanM L Berman
Aug 6, 1997·Journal of the National Cancer Institute·M C PikeT M Mack
May 29, 2001·Journal of Clinical Pathology·K M Feeley, M Wells
Oct 12, 2001·Annals of the New York Academy of Sciences·A AkhmedkhanovP Toniolo
Aug 9, 2005·Lancet·Frederic AmantIgnace Vergote
Oct 6, 2005·American Journal of Obstetrics and Gynecology·Vivian E von GruenigenMichael P Hopkins
Dec 21, 2005·Best Practice & Research. Clinical Obstetrics & Gynaecology·Yukio Sonoda, Richard R Barakat
Feb 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Richard R BarakatUNKNOWN Gynecologic Oncology Group Study
May 10, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·A AyhanAtike Sever
Sep 8, 2009·Maturitas·Lynne T ShusterWalter A Rocca
Mar 2, 2011·Climacteric : the Journal of the International Menopause Society·A H MacLennan
Mar 16, 2012·The Cochrane Database of Systematic Reviews·Anthony KongTheresa A Lawrie
Apr 26, 2012·BJOG : an International Journal of Obstetrics and Gynaecology·O SvejmeM K Karlsson
Sep 14, 2012·The Cochrane Database of Systematic Reviews·Khadra GalaalAlberto D Lopes
Mar 15, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J FerlayF Bray
Apr 2, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Seung-Hyuk ShimSoo-Nyung Kim
May 17, 2014·The Cochrane Database of Systematic Reviews·Khadra GalaalTheresa A Lawrie
Dec 23, 2014·Future Oncology·M Aamir SheikhFaina Linkov
Apr 8, 2015·Climacteric : the Journal of the International Menopause Society·S S FaubionW A Rocca
Apr 11, 2015·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Lesley B ConradMichael Frumovitz
Aug 6, 2015·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Maria KyrgiouJane Warwick
Oct 1, 2015·International Journal of Cancer. Journal International Du Cancer·Lina S MørchØjvind Lidegaard
Nov 14, 2015·BMJ : British Medical Journal·Grammati SarriUNKNOWN Guideline Development Group
Nov 2, 2016·The Cochrane Database of Systematic Reviews·Giulio FormosoEmilio Maestri
Jan 18, 2017·The Cochrane Database of Systematic Reviews·Jane MarjoribanksJasmine Lee
Oct 3, 2017·The Cochrane Database of Systematic Reviews·Jonathan A FrostJo Morrison
Nov 25, 2017·BMJ : British Medical Journal·Martha HickeyMyra S Hunter

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Cochrane Database of Systematic Reviews
Jonathan A FrostJo Morrison
The Cochrane Database of Systematic Reviews
Jonathan A FrostJo Morrison
The Cochrane Database of Systematic Reviews
George U ElejeLydia I Eleje
The Cochrane Database of Systematic Reviews
Theresa A LawrieHenry C Kitchener
© 2022 Meta ULC. All rights reserved