Hormone replacement therapy in endometrial cancer survivors: new perspectives after the heart and estrogen progestin replacement study and the women's health initiative

Journal of Lower Genital Tract Disease
Brian A McDonnell, Leo B Twiggs

Abstract

Dramatic shifts in prescription practices during the last 30 years have left physicians confused and uncertain about the use of hormone replacement therapy (HRT) in endometrial cancer survivors. This article reviews the published literature concerning both the safety of prescribing HRT to endometrial cancer survivors and the therapy s potential risks and benefits. Prescribing HRT to endometrial cancer survivors does not seem to be contraindicated and may even confer modest protection, depending on the doses and the specific drugs used. The potential benefits of HRT are more conflicting. Although the medical community agrees on the positive effects for bone density and relief of vasomotor symptoms, the results of our review offer no clear consensus in regard to HRT's effects on coronary heart disease, health-related quality of life, cognitive functioning, and cancer incidence. Until the medical community can concur on the proper prescription practices in endometrial cancer survivors, an individualized patient-based approach must be taken.

References

Mar 15, 1977·American Journal of Obstetrics and Gynecology·T W McDonaldL T Kurland
Jan 4, 1979·The New England Journal of Medicine·C M AntunesR Garcia
Jul 20, 1979·JAMA : the Journal of the American Medical Association·N S WeissA I Schweid
May 1, 1980·American Journal of Obstetrics and Gynecology·B S HulkaC C Pulliam
Feb 1, 1995·Obstetrics and Gynecology·D GradyD Petitti
Nov 1, 1996·American Journal of Obstetrics and Gynecology·J A ChapmanM L Berman
Jul 7, 1999·Journal of the National Cancer Institute·E WeiderpassI Persson
Apr 29, 2000·Journal of Clinical Epidemiology·M G JainG R Howe
Dec 20, 2000·American Journal of Obstetrics and Gynecology·D A HillS Self
Jun 27, 2001·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·UNKNOWN Committee on Gynecologic Practice
Jul 1, 1994·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·B.G. Wren
Jul 2, 2002·JAMA : the Journal of the American Medical Association·Deborah GradyUNKNOWN HERS Research Group
Jul 19, 2002·JAMA : the Journal of the American Medical Association·Jacques E RossouwUNKNOWN Writing Group for the Women's Health Initiative Investigators
Mar 19, 2003·The New England Journal of Medicine·Jennifer HaysUNKNOWN Women's Health Initiative Investigators
Aug 9, 2003·The New England Journal of Medicine·JoAnn E MansonUNKNOWN Women's Health Initiative Investigators
Oct 2, 2003·JAMA : the Journal of the American Medical Association·Garnet L AndersonUNKNOWN Women's Health Initiative Investigators
Oct 4, 2003·American Journal of Obstetrics and Gynecology·William T CreasmanPhilip J Disaia
Apr 15, 2004·JAMA : the Journal of the American Medical Association·Garnet L AndersonUNKNOWN Women's Health Initiative Steering Committee
Jun 30, 2004·Maturitas·Piero Sismondi, Nicoletta Biglia
Aug 12, 2004·International Journal of Cancer. Journal International Du Cancer·Kjersti BakkenEiliv Lund
Sep 1, 2004·Maturitas·Elizabeth Anderson
Oct 28, 2004·American Journal of Obstetrics and Gynecology·Susan D ReedNoel S Weiss
Nov 16, 2004·Endocrine·S Mitchell HarmanFrederick Naftolin
Dec 14, 2004·Women's Health Issues : Official Publication of the Jacobs Institute of Women's Health·Paula S Derry
Jan 27, 2005·Climacteric : the Journal of the International Menopause Society·I RudolphT Gräser

❮ Previous
Next ❯

Citations

Sep 22, 2007·Best Practice & Research. Clinical Obstetrics & Gynaecology·Andrea Garrett, Michael A Quinn
May 4, 2007·Menopause : the Journal of the North American Menopause Society·Arthur F Haney, Robert A Wild

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.