Hormone replacement therapy is associated with improved arterial physiology in healthy post-menopausal women

Clinical Endocrinology
J A McCrohonD S Celermajer

Abstract

Oestrogen replacement therapy is associated with a marked reduction in coronary event rates in post-menopausal women. As older age is associated with progressive arterial endothelial damage, a key event in atherosclerosis, we assessed whether hormone replacement therapy (HRT) with oestrogen alone, or oestrogen and progesterone combined, is associated with improved endothelial function in healthy women after the menopause. Using high resolution external vascular ultrasound, brachial artery diameter was measured at rest and in response to reactive hyperaemia, with increased flow causing endothelium-dependent dilatation (flow-mediated dilatation). We investigated 135 healthy women; 40 were pre-menopausal (mean +/- SD age/26 +/- 6 years, group 1), 40 were post-menopausal and had never taken HRT (aged 58 +/- 3 years; group 2) and 55 were age-matched post-menopausal women who had taken HRT for > or = 2 years, from within 2 years of the menopause (aged 57 +/- 4 years; group 3). In group 3, 40 women were on combined oestrogen and progesterone and 15 on oestrogen-only HRT. In group 2, flow-mediated dilatation was significantly reduced compared with group 1 (4.4 +/- 3.4 vs 9.6 +/- 3.6%, P < 0.001), consistent with a decline in arterial e...Continue Reading

Citations

Dec 21, 2000·Current Atherosclerosis Reports·L Mosca
Mar 10, 2001·Obstetrics and Gynecology·T Naessen, O Bakos
May 19, 2001·Maturitas·Y T van der Schouw, D E Grobbee
May 20, 2003·Maturitas·Marlies E OssewaardeDiederick E Grobbee
Jun 1, 1997·Journal of the American College of Cardiology·J A McCrohonD S Celermajer
Aug 1, 1997·Journal of the American College of Cardiology·D S Celermajer
Apr 17, 2008·The Proceedings of the Nutrition Society·Gordon A A Ferns
Dec 3, 1999·European Journal of Clinical Investigation·W M Van BaalC D Stehouwer
Mar 21, 2002·Journal of Internal Medicine·B Guzic-SalobirL Vrabic
Jun 1, 2005·Nutrition Research Reviews·Wendy L HallChristine M Williams
Feb 24, 2001·Antioxidants & Redox Signaling·D T PriceJ F Keaney
Jun 22, 2007·Clinical and Experimental Pharmacology & Physiology·H J Teede
Oct 23, 2004·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·E CerquetaniG M C Rosano
Feb 9, 2012·Maturitas·A Virdis, S Taddei
Nov 14, 1997·Mayo Clinic Proceedings·D L Hurley, S Khosla
Mar 3, 2005·Biological Psychology·Karen A MatthewsSarah L Berga
Oct 19, 2004·Atherosclerosis·André Arpad FaludiJose Eduardo M R Sousa
Oct 22, 2003·Clinics in Geriatric Medicine·Stanley J Birge
Jul 24, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Levent AkmanMustafa Akin
Jul 16, 2005·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·José M AldrighiJosé Antônio F Ramires
Nov 1, 2005·Expert Opinion on Investigational Drugs·Dirk C Felmeden, Gregory Y H Lip
Dec 24, 2002·The Journal of Pharmacy and Pharmacology·Meili ZhangPeter K T Pang
Jan 25, 2003·The Journal of Pharmacy and Pharmacology·Meili ZhangPeter K T Pang

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