Hormone replacement therapy reduces the reactivity of monocytes and platelets in whole blood--a beneficial effect on atherogenesis and thrombus formation?

American Journal of Obstetrics and Gynecology
B AuneB Osterud

Abstract

Our purpose was to investigate the effects of hormone replacement therapy on the reactivity of monocytes and platelets in whole blood, measured by tissue factor activity, tumor necrosis factor-alpha, and thromboxane B2. Thirty-two women were randomized into either transdermal or oral combined hormone replacement therapy and underwent blood sampling before and after 3 and 12 months of treatment. The tissue factor activity in monocytes was measured both in unstimulated whole blood and after a weak lipopolysaccharide stimulation. Tumor necrosis factor-alpha and thromboxane B2 formation in plasma were measured after a weak lipopolysaccharide stimulation of whole blood. After 12 months of hormone replacement therapy there were significant reductions of tissue factor activity in both unstimulated and lipopolysaccharide-stimulated monocytes (p < 0.001) and significant reductions in the formation of tumor necrosis factor-alpha (p < 0.03) and thromboxane B2 (p < 0.02). There were no differences in these parameters between the transdermal and the oral groups. No changes were observed after 3 months of therapy. Twelve months of hormone replacement therapy reduces cellular activation of blood monocytes and platelets; these changes may acco...Continue Reading

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·B Osterud, S I Rapaport
Jun 1, 1976·Scandinavian Journal of Immunology·A Bøyum
Apr 10, 1991·JAMA : the Journal of the American Medical Association·E Barrett-Connor, T L Bush
Sep 1, 1990·Maturitas·P M Sarrel
Dec 1, 1990·Archives of Internal Medicine·J M SullivanD M Mirvis
Feb 1, 1990·The American Journal of Cardiology·P BarathJ S Forrester
May 1, 1988·American Heart Journal·H W GruchowK A Sobocinski
Jan 1, 1987·Prostaglandins, Leukotrienes, and Medicine·R PunnonenK Punnonen
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·B J Van LentenP A Edwards
Oct 16, 1986·The New England Journal of Medicine·D J FitzgeraldG A FitzGerald
Feb 25, 1993·The American Journal of Cardiology·C J SchwartzE A Sprague

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Citations

Dec 31, 2003·The Journal of Surgical Research·Lauren BakerDaniel R Meldrum
Feb 16, 2000·Obstetrics and Gynecology·M G DuránA López Farré
Mar 16, 2000·Maturitas·M Calvin
May 29, 2004·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Maria Cinta García-MartínezAntonio Cano
Sep 13, 2003·The Journal of Cardiovascular Nursing·S Penckofer, D Schwertz
Feb 1, 1997·British Journal of Obstetrics and Gynaecology·B W Hartmann, J C Huber
Nov 4, 2005·Biological Research for Nursing·Marguerite T Littleton-KearneyPatricia D Hurn
Jul 26, 2002·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·B ØsterudJ O Olsen
Nov 6, 2007·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Anatol PanasiukDanuta Prokopowicz
Jan 10, 2006·BJOG : an International Journal of Obstetrics and Gynaecology·Dianna J MaglianoAndrew M Tonkin
Jul 9, 2002·Best Practice & Research. Clinical Obstetrics & Gynaecology·George I Gorodeski
Sep 20, 2005·American Heart Journal·Marlene S WilliamsPamela Ouyang
Apr 4, 1998·The Annals of Thoracic Surgery·C H SelzmanB C Cain
Feb 28, 2015·Aging Cell·Carmen Giefing-KröllBeatrix Grubeck-Loebenstein
Jun 21, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Muthuvel JayachandranVirginia M Miller
Nov 30, 2005·American Journal of Hematology·Tariq M RoshanLin Naing
Jun 28, 2019·International Journal of Molecular Sciences·Marion DupuisMarie-Cécile Valéra
Jul 21, 2007·Endocrine Reviews·Rainer H Straub
Jul 31, 2020·Endocrinology·Franck Mauvais-JarvisEllis R Levin
Aug 19, 1999·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·C BattagliaA Volpe

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