PMID: 15220197Jun 29, 2004Paper

Hormone-sensitive lipase has a role in lipid signaling for insulin secretion but is nonessential for the incretin action of glucagon-like peptide 1

Diabetes
Marie-Line PeyotMarc Prentki

Abstract

We previously reported decreased glucose-stimulated insulin secretion (GSIS) in hormone-sensitive lipase-null mice (HSL(-/-)), both in vivo and in vitro. The focus of the current study was to gain further insight into the signaling role and regulation of lipolysis in islet tissue. The effect of glucagon-like peptide 1 (GLP-1) on GSIS was also studied, as GLP-1 could augment GSIS via protein kinase A activation of HSL and lipolysis. Freshly isolated islets from fasted and fed male HSL(-/-) and wild-type (HSL(+/+)) mice were studied at ages 4 and 7 months. Neutral cholesteryl ester hydrolase activity was markedly reduced in islets from both 4- and 7-month-old male HSL(-/-) mice, whereas a marked deficiency in triglyceride lipase activity became evident only in the older mice. The deficiencies in lipase activities were associated with higher islet triglyceride content and reduced lipolysis at basal glucose levels. Lipolysis was stimulated by high glucose in islets of both wild-type and HSL-null mice. Severe deficiencies in GSIS were found, but only in islets from 7-month-old, fasted, male HSL(-/-) mice. GSIS was less affected in 4-month-old fasted male HSL(-/-) mice and not reduced in female mice. Exogenous delivery of free fatty ...Continue Reading

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Citations

Jun 16, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A Girousse, D Langin
Apr 25, 2009·The Journal of Biological Chemistry·Marie-Line PeyotMarc Prentki
May 9, 2007·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Julien LamontagneChristopher James Nolan
Jul 11, 2006·The Journal of Clinical Investigation·Marc Prentki, Christopher J Nolan
Feb 14, 2006·Nutrition & Metabolism·Fredric B Kraemer, Wen-Jun Shen
Jan 10, 2013·Diabetology & Metabolic Syndrome·Rodrigo N LamounierMaria Lúcia Corrêa-Giannella
May 30, 2014·Nutrition Research Reviews·Gema FrühbeckAmaia Rodríguez
Jul 22, 2009·Biochemical and Biophysical Research Communications·Motohiro SekiyaJun-ichi Osuga
Sep 9, 2008·Trends in Endocrinology and Metabolism : TEM·Christopher J Nolan, Marc Prentki
Feb 12, 2008·Physiology & Behavior·Johan W E Jocken, Ellen E Blaak
Apr 29, 2005·Diabetes/metabolism Research and Reviews
Jun 13, 2006·Diabetes Research and Clinical Practice·Wen-Jun ShenFredric B Kraemer
Nov 24, 2011·Molecular and Cellular Endocrinology·Marc Prentki, S R Murthy Madiraju
Jun 25, 2013·Cell Metabolism·Marc PrentkiS R Murthy Madiraju
Oct 28, 2008·Journal of Lipid Research·Rudolf ZechnerAchim Lass
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Aug 11, 2005·American Journal of Physiology. Endocrinology and Metabolism·Liping HuBarbara E Corkey
Jul 9, 2008·Endocrine Reviews·Marc Prentki, S R Murthy Madiraju
Oct 12, 2007·The Journal of Biological Chemistry·Claudiane GuayMarc Prentki
Nov 30, 2006·Diabetes·Christopher J NolanMarc Prentki
Sep 17, 2008·Biochemical Society Transactions·Malin Fex, Hindrik Mulder

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