HORMONE SUBSTITUTION AFTER GASTRIC BYPASS SURGERY IN PATIENTS WITH HYPOPITUITARISM SECONDARY TO CRANIOPHARYNGIOMA.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
Peter WolfMichael Krebs

Abstract

Craniopharyngiomas (CPs) are benign brain tumors presenting frequently in childhood and are treated by surgery with or without radiotherapy. About 50% of cured patients suffer from eating disorders and obesity due to hypothalamic damage, as well as hypopituitarism, necessitating subsequent hormone substitution therapy. Gastric bypass surgery has been reported to be an efficient treatment strategy for morbid hypothalamic obesity. However, so far it is unknown whether oral hormone substitution is affected by impaired intestinal drug absorption, potentially leading to severe hypopituitarism or pituitary crisis. Four morbidly obese CP patients with panhypopituitarism treated by gastric bypass surgery were included in this retrospective analysis. Dosages of hormone substitution therapy, blood concentrations of hormones, potential complications of impaired drug absorption, and anthropometric characteristics were investigated pre- and postoperatively after 6 to 14 months and 13 to 65 months. In all CP patients (3 female/1 male; baseline body mass index, 49 ± 7 kg/m(2)), gastric bypass resulted in distinct weight loss (-35 ± 27 kg). In follow-up examinations, mean daily dosage of thyroid hormone (levothyroxinebaseline 156 ± 44 μg/day v...Continue Reading

References

Aug 1, 1995·The Journal of Clinical Investigation·S K GrinspoonA Klibanski
Jan 13, 2004·The Journal of Clinical Endocrinology and Metabolism·S SrinivasanC T Cowell
May 25, 2007·The New England Journal of Medicine·Eric J DeMaria
Jul 24, 2007·Nature Clinical Practice. Endocrinology & Metabolism·Thomas H IngeMatthias H Tschöp
May 5, 2009·European Journal of Endocrinology·Bernd SchultesMartin Thurnheer
Jun 6, 2009·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·R PadwalA M Sharma
Oct 17, 2009·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Jacqueline Jonklaas
Dec 8, 2009·Journal of Pediatric Endocrinology & Metabolism : JPEM·Diane RottembourgCéline Huot
Aug 27, 2010·The American Journal of Clinical Nutrition·Elizabeth A OdstrcilJohn S Fordtran
Sep 30, 2010·Nature Reviews. Endocrinology·Hermann L Müller
Apr 22, 2011·The Journal of Clinical Endocrinology and Metabolism·Hermann L Müller
Jun 3, 2011·Obesity Surgery·Ileana Gabriela Sanchez RubioGeraldo Medeiros-Neto
Apr 18, 2012·Clinical Endocrinology·Dirk WeismannBruno Allolio
Jan 1, 2011·Frontiers in Endocrinology·Robert H Lustig
Aug 7, 2012·Best Practice & Research. Clinical Endocrinology & Metabolism·Eva Fernandez-RodriguezFelipe F Casanueva
Sep 11, 2012·Pituitary·Eva Marie ErfurthSigridur Bara Fjalldal
Sep 22, 2012·Clinical Endocrinology·Blandine GattaAntoine Tabarin
Mar 28, 2013·The Journal of Clinical Endocrinology and Metabolism·Marion BretaultSébastien Czernichow
Jun 26, 2013·Nature Reviews. Endocrinology·Hermann L Müller
Dec 24, 2013·The Journal of Endocrinology·Pouneh K Fazeli, Anne Klibanski
Jan 29, 2014·Endocrine Reviews·Hermann L Müller
Apr 1, 2014·The New England Journal of Medicine·Philip R SchauerUNKNOWN STAMPEDE Investigators

❮ Previous
Next ❯

Citations

Nov 1, 2016·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M WijnenS J C M M Neggers
Jun 5, 2021·The Journal of Clinical Endocrinology and Metabolism·Anna Otte, Hermann L Müller
Nov 5, 2019·Neuroendocrinology·Hermann L Müller

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addison Disease

Addison's disease, also known as primary adrenal insufficiency and hypocortisolism, is a long-term endocrine disorder in which the adrenal glands do not produce enough steroid hormones. Discover the latest research on Addison's disease here.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.