Hormone therapy and breast cancer: what factors modify the association?

Menopause : the Journal of the North American Menopause Society
Dorota M GertigGraham G Giles

Abstract

To determine factors that may modify the association between hormone therapy (HT) and breast cancer risk. Prospective cohort study (the Melbourne Collaborative Cohort Study) of 24,479 women aged 40 to 69 years. History of HT use was collected at baseline and 4 years later by questionnaire. By June 2002, 336 cases of breast cancer were diagnosed among 13,444 women postmenopausal at baseline. Association of breast cancer risk with history of HT use was analyzed using proportional hazards models. The hazard ratio (HR) for recent HT use (current or stopped within the last year) was elevated (HR 1.51; 95% CI, 1.16-1.98) but was not significantly increased for past HT users (HR 1.19; 95% CI, 0.86-1.64). Recent HT use was associated with better differentiated tumors but was not more likely to be associated with estrogen receptor-positive / progesterone receptor-positive tumors. There was little evidence of interactions between recent HT use and body mass index, alcohol intake, parity, and smoking, although the HR for recent HT use in categories of alcohol consumption was greatest in women consuming the most alcohol (HR 2.37; 95% CI, 1.45-3.88 for those consuming > or = 10 g/d versus HR 1.33; 95% CI, 0.85-2.08 for nondrinkers, P intera...Continue Reading

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Citations

Apr 29, 2006·Menopause : the Journal of the North American Menopause Society·Andrew M Kaunitz
Jan 2, 2007·Advances in Anatomic Pathology·I-Tien Yeh
Nov 26, 2015·International Journal of Cancer. Journal International Du Cancer·Usha SalagameKaren Canfell
Oct 7, 2015·Australian and New Zealand Journal of Public Health·Susan J JordanPenelope M Webb
May 28, 2013·Asia-Pacific Journal of Public Health·Thunyarat AnothaisintaweeAmmarin Thakkinstian
Aug 8, 2018·European Journal of Epidemiology·Marie Søfteland SandveiSigne Opdahl
Jun 11, 2017·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Hazel B NicholsAnthony J Swerdlow

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