Hormone therapy and risk of venous thromboembolism among postmenopausal women in Taiwan - a 10-year nationwide population-based study

Circulation Journal : Official Journal of the Japanese Circulation Society
Cheng-Han LeeLi-Jen Lin

Abstract

The incidence of venous thromboembolism (VTE) in Asians is lower than in Caucasians, but the risk of VTE associated with hormone therapy (HT) in Taiwanese postmenopausal women has not been determined. From Taiwan's National Health Insurance Research Database, we established matched cohorts (HT users and nonusers) of postmenopausal women aged ≥50 years between 1 January 1998 and 31 December 2008. We calculated the 2-year incidence of VTE in HT users and nonusers. HT users and nonusers were matched 1:1 based on propensity-score matching. Cox regression hazard model was used to identify risk factors of VTE. We initially identified 499,594 HT users and 424,963 nonusers. There were higher percentages of cancer and cardiovascular events among the HT nonusers. After matching, the VTE incidence was 4.4 vs. 2.6 per 10,000 patient-years (adjusted hazard ratio 1.796, 95% confidence interval 1.272-2.537) in HT users and nonusers, respectively. The Cox regression hazard model showed that HT use, older age, malignancy, heart failure, and recent major surgery were independent risk factors for VTE. Although the incidence of VTE was very low among this cohort of Taiwanese postmenopausal women, oral HT was still associated with an increased risk...Continue Reading

References

Sep 1, 1988·International Journal of Cardiology·K S WooJ Vallance-Owen
Jul 2, 2002·JAMA : the Journal of the American Medical Association·Stephen HulleyUNKNOWN HERS Research Group
Jul 19, 2002·JAMA : the Journal of the American Medical Association·Jacques E RossouwUNKNOWN Writing Group for the Women's Health Initiative Investigators
Feb 8, 2003·BMJ : British Medical Journal·Janice RymerKaren Ballard
Aug 21, 2003·Lancet·Pierre-Yves ScarabinUNKNOWN EStrogen and THromboEmbolism Risk Study Group
Feb 6, 2004·Annals of Internal Medicine·Jennifer S HaasKarla Kerlikowske
Mar 30, 2004·The British Journal of Surgery·B L Y CheukS W K Cheng
Apr 15, 2004·JAMA : the Journal of the American Medical Association·Garnet L AndersonUNKNOWN Women's Health Initiative Steering Committee
Oct 7, 2004·JAMA : the Journal of the American Medical Association·Mary CushmanUNKNOWN Women's Health Initiative Investigators
Jul 30, 2005·Seminars in Thrombosis and Hemostasis·Tomoko Adachi, Shoichi Sakamoto
Apr 12, 2006·Archives of Internal Medicine·J David CurbFrits R Rosendaal
Jan 1, 2007·Women's Health·Gordon D O Lowe
Mar 30, 2010·Journal of Thrombosis and Haemostasis : JTH·C-H LeeL-M Tsai
Mar 29, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·UNKNOWN JCS Joint Working Group
May 14, 2011·Climacteric : the Journal of the International Menopause Society·D W SturdeeJ C Stevenson
Jun 24, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Cheng-Han LeeYea-Huei Kao Yang
Jul 13, 2012·The Cochrane Database of Systematic Reviews·Jane MarjoribanksAnne Lethaby
Jun 14, 2013·Menopause International·Nick PanayUNKNOWN British Menopause Society and Women's Health Concern
Jan 10, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Mashio NakamuraTetsuhito Kojima

❮ Previous
Next ❯

Citations

Jul 12, 2016·International Journal of Molecular Sciences·Ben-Shian HuangPeng-Hui Wang
Jun 29, 2018·Circulation Journal : Official Journal of the Japanese Circulation Society·Tetsuya OhiraUNKNOWN JACC Study Group
Sep 1, 2017·Pharmacoepidemiology and Drug Safety·Wan-Ju Annabelle LeeCheng-Yang Hsieh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.