Hormone therapy in the WHI era

The Australian & New Zealand Journal of Obstetrics & Gynaecology
Henry G Burger

Abstract

The announcement in July 2002 in the media of the results of the combined continuous hormone treatment arm of the Women's Health Initiative (WHI) had a profound effect on perceptions about hormone therapy among the lay public and the medical profession. Careful scrutiny of the announcement and the subsequent publications leads to the conclusion that the widespread fear of hormone therapy that was generated was not supported by the facts. WHI was not designed to be, nor can it be, interpreted as a randomised controlled trial of menopausal hormone therapy--rather, it was a trial of chronic disease prevention, particularly aimed at the possible cardiovascular benefits of a specific combination hormone therapy in postmenopausal women. The results, which were consistent with existing data, did not and do not warrant any major change in the previously established guidelines for the use of hormone therapy. Tibolone has emerged as an alternative treatment for menopausal symptoms, but its long-term benefits and risks have yet to be documented.

References

Jul 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·J K WilliamsT B Clarkson
Oct 1, 1995·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·G Samsioe
Aug 15, 1996·The New England Journal of Medicine·F GrodsteinC H Hennekens
May 22, 2002·JAMA : the Journal of the American Medical Association·Robert LindsayJames H Pickar
Jul 19, 2002·JAMA : the Journal of the American Medical Association·Jacques E RossouwUNKNOWN Writing Group for the Women's Health Initiative Investigators
Nov 7, 2002·JAMA : the Journal of the American Medical Association·Peter P ZandiUNKNOWN Cache County Memory Study Investigators
Jan 7, 2003·Annals of Internal Medicine·Alka M KanayaUNKNOWN Heart and Estrogen/progestin Replacement Study
Mar 19, 2003·The New England Journal of Medicine·Jennifer HaysUNKNOWN Women's Health Initiative Investigators
May 24, 2003·Best Practice & Research. Clinical Endocrinology & Metabolism·Roger E Peverill
Jun 26, 2003·JAMA : the Journal of the American Medical Association·Rowan T ChlebowskiUNKNOWN WHI Investigators
Aug 9, 2003·The New England Journal of Medicine·JoAnn E MansonUNKNOWN Women's Health Initiative Investigators
Aug 28, 2003·JAMA : the Journal of the American Medical Association·Karen M PrestwoodMartin Kulldorff
Sep 30, 2003·Diabetes Care·Katherine M NewtonWilliam Barlow
Mar 5, 2004·The New England Journal of Medicine·Rowan T ChlebowskiUNKNOWN Women's Health Initiative Investigators
Apr 15, 2004·JAMA : the Journal of the American Medical Association·Garnet L AndersonUNKNOWN Women's Health Initiative Steering Committee
Oct 23, 2004·Climacteric : the Journal of the International Menopause Society·Henry BurgerUNKNOWN Expert Workshop
Jan 27, 2005·Climacteric : the Journal of the International Menopause Society·H Kuhl
Mar 8, 2005·Fertility and Sterility·Lawrence S Phillips, Robert D Langer
Apr 1, 2005·Climacteric : the Journal of the International Menopause Society·F NaftolinUNKNOWN Executive Committee of the International Menopause Society
May 11, 2005·Maturitas·P KenemansUNKNOWN International Tibolone Consensus Group
Sep 8, 2005·Menopause : the Journal of the North American Menopause Society·James A Simon

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Citations

Dec 20, 2007·Menopause : the Journal of the North American Menopause Society·Amanda DeeksHelena Teede
Jan 12, 2008·Menopause : the Journal of the North American Menopause Society·Ruey-Jien ChenSong-Nan Chow
Aug 20, 2010·Journal of Medical Case Reports·Carolyn J ClarkDavid W Mudge
Dec 3, 2011·Climacteric : the Journal of the International Menopause Society·P SayakhotH Teede
May 24, 2011·Revista española de geriatría y gerontología·Cristina Alonso-Bouzon, Gustavo Duque
Mar 21, 2007·Maturitas·Henry G Burger
Oct 21, 2015·Journal of Biomechanics·Peng JiangZhao Chen
May 6, 2008·Journal of the American Geriatrics Society·Gustavo Duque, Bruce R Troen
Jun 22, 2007·Clinical and Experimental Pharmacology & Physiology·H J Teede
Apr 28, 2006·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Helen E Roberts, Cynthia M Farquhar
Nov 6, 2007·Molecular and Cellular Biochemistry·Rauf Onur EkTulay Kavak

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