Hormone therapy initiation after the Women's Health Initiative

Menopause : the Journal of the North American Menopause Society
Katherine M NewtonK Arnold Chan

Abstract

To describe hormone therapy (HT) initiation after the 2002 publication of the Women's Health Initiative. Observational cohort (1999-2003) of women ages 40 to 79 years, five health plans, used HT in July 2002 and subsequently discontinued or never used before August 2002. Of discontinuers, 15.8% (3,203 of 20,205) reinitiated HT. Reinitiation was higher among estrogen users (23.8%) versus estrogen with progestin users (11.3%), and lower among those with diabetes (relative risk [RR]=0.68, 95% CI: 0.61-0.76), cardiovascular disease (RR=0.87, 95% CI: 0.83-0.92), and hyperlipidemia (RR=0.83, 95% CI: 0.79-0.88). Only 2.3% (2,072 of 90,261) of never users initiated (August 2002 to December 2003). First-time initiation was associated with cardiovascular disease (RR=1.17, 95% CI: 1.10-1.25) and hyperlipidemia (RR=1.24, 95% CI: 1.17-1.33) and was less common among those with diabetes (RR=0.70, 95% CI: 0.63-0.79). After the Women's Health Initiative, a minority of women reinitiated or became first-time initiators of HT. Women with cardiovascular disease, diabetes, and hyperlipidemia were less likely to reinitiate; women with cardiovascular disease and hyperlipidemia were more likely to be first-time initiators.

References

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Nov 17, 2004·Menopause : the Journal of the North American Menopause Society·UNKNOWN North American Menopause Society
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Citations

Feb 11, 2009·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Natalia Gavrilova, Stacy Tessler Lindau
Mar 5, 2011·Menopause : the Journal of the North American Menopause Society·James Francis CarmodyNicholas Olendzki
Nov 5, 2010·The Journal of Nutrition·Silvina Levis, Marcio L Griebeler
Mar 1, 2010·Female Pelvic Medicine & Reconstructive Surgery·Keisha A Jones, Pamela A Moalli
Oct 29, 2010·Climacteric : the Journal of the International Menopause Society·K M NewtonD S M Buist
Jul 31, 2013·American Journal of Human Biology : the Official Journal of the Human Biology Council·Lynnette Leidy Sievert

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