PMID: 9535600Apr 16, 1998Paper

Hormone/antihormone withdrawal and dexamethasone for hormone-refractory prostate cancer

International Journal of Urology : Official Journal of the Japanese Urological Association
T Nishiyama, M Terunuma

Abstract

Flutamide withdrawal has been reported to benefit patients with hormone-refractory prostate cancer. Several studies have also demonstrated that a combination of corticosteroids and testicular androgen ablation lowers serum androgen levels and improves clinical response. The purpose of this study was to examine the effect of withdrawal of oral hormonal agents and administration of dexamethasone in stage D3 prostate cancer patients. Sixteen patients with hormone-refractory prostate cancer were enrolled in the study. All patients had osseous metastasis and elevated serum prostate-specific antigen. Nine had been treated with chlormadinone acetate, 4 with estramustine phosphate, and 3 with flutamide as first-line hormonal therapy. All patients had also been treated either with bilateral orchiectomy (13 cases) or a luteinizing hormone-releasing hormone (LH-RH) agonist (3 cases). Seven patients whose disease progressed following hormone withdrawal were treated with oral dexamethasone (initially 1.5 mg/day, then tapered to 0.5 mg/day). Eight patients demonstrated a decrease in prostate-specific antigen of greater than 50% following hormone withdrawal. The time to cancer progression for these 8 patients was 2 to 15 months (mean, 4 month...Continue Reading

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Dec 1, 1994·International Journal of Urology : Official Journal of the Japanese Urological Association·T Nishiyama, M Terunuma
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Citations

Jun 6, 2003·Cancer Treatment Reviews·Cynthia L MartelPrimo N Lara
Apr 28, 2001·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·G Mathé
Dec 9, 2015·Nature Reviews. Urology·Sujata NarayananDavid Feldman
Aug 3, 2006·International Journal of Urology : Official Journal of the Japanese Urological Association·Mizuki KobayashiNaohiro Fujimoto
Jul 29, 2004·Annales D'urologie·C Linke, P Mongiat-Artus
Apr 1, 2004·International Journal of Cancer. Journal International Du Cancer·Teruaki KumazawaTomonori Habuchi
Jun 8, 2001·International Journal of Urology : Official Journal of the Japanese Urological Association·T SaikaUNKNOWN Okayama Urological Cancer Collaborating Group
Sep 24, 2004·International Journal of Urology : Official Journal of the Japanese Urological Association·Tsutomu NishiyamaKota Takahashi
Nov 21, 2000·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·R Paul, J Breul
Jan 1, 2010·Oncology Letters·Akira KomiyaTomohiko Ichikawa

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