Hormones and antioxidant systems: role of pituitary and pituitary-dependent axes.

Journal of Endocrinological Investigation
A ManciniA Pontecorvi

Abstract

Oxidative stress, a condition defined as unbalancing between production of free radicals and antioxidant defenses, is an important pathogenetic mechanism in different diseases. Despite the abundant literature, many aspects of hormone role in regulating antioxidant synthesis and activity still remain obscure. Therefore, we reviewed experimental data, in vivo and in vitro, about the effects of the different pituitary- dependent axes on antioxidant levels, trying to give a broad view from hormones which also have antioxidant properties to the classic antioxidants, from the lipophilic antioxidant Coenzyme Q10, strictly related to thyroid function, to total antioxidant capacity, a measure of non-protein non-enzymatic antioxidants in serum and other biological fluids. Taken together, these data underline the importance of oxidative stress in various pituitary-dependent disorders, suggesting a possible clinical usefulness of antioxidant molecules.

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Citations

Nov 1, 2012·Nutrition Reviews·Florence M Sohet, Nathalie M Delzenne
Jul 7, 2016·Indian Journal of Clinical Biochemistry : IJCB·A S ThakurP Chauhan
Apr 7, 2016·Mediators of Inflammation·Antonio ManciniDiego Currò
Jan 3, 2013·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Na WeiLiu Hong
Jan 25, 2012·International Journal of Molecular Sciences·Antonio ManciniGian Paolo Littarru
Dec 20, 2013·International Journal of Molecular Sciences·Antonio ManciniElisabetta Meucci
Dec 24, 2019·Free Radical Research·Gagan B N Chainy, Dipak Kumar Sahoo
Feb 11, 2021·International Journal of Molecular Sciences·Antonio ManciniAndrea Silvestrini

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