Hormones of the hypothalamo-pituitary-gonadal axis in drug discrimination learning

Pharmacology, Biochemistry, and Behavior
R de Beun

Abstract

More than 30 years ago, T-maze studies with progesterone indicated that sex hormones have the potential to act as a discriminative stimulus in rats. Despite these early positive findings, the interest in discriminative stimulus properties of sex hormones remained low; few studies were dedicated to the investigation of discriminative stimulus properties of hypothalamo-pituitary-gonadal axis hormones (i.e., LHRH, LH/FSH, sex steroids). Nevertheless, the few studies that were published showed some interesting, and often sex-dependent results. Applying various methodologies (T-, or Y-maze, two-lever drug discrimination, taste aversion procedures), it was found that not only progesterone but also the two other principal sex steroids estradiol and testosterone can serve as discriminative stimuli in rodents. In addition to these gonadal hormones, the hypothalamic peptide LHRH (having a key role in the neuroendocrine regulation of steroid release from the gonads) appears to generate discriminative stimulus properties. Interestingly, recent (but preliminary) studies in postmenopausal women suggest that estradiol (and possibly progesterone) may also function as a discriminative stimulus in human subjects.

References

Apr 1, 1977·Hormones and Behavior·P Gray
Nov 1, 1992·Psychoneuroendocrinology·R de BeunN E van de Poll
Jan 1, 1992·Psychoneuroendocrinology·R de BeunN E van de Poll
Jan 1, 1986·Acta Neurologica Scandinavica. Supplementum·T U Järbe
Nov 1, 1987·Pharmacology, Biochemistry, and Behavior·R P HeinsbroekN E van de Poll
Dec 23, 1967·Nature·J StewartE Kaczender
Aug 1, 1972·The Quarterly Journal of Experimental Psychology·J T RickG A Kerkut
Sep 1, 1981·Behavioral and Neural Biology·D L EbnerD C Riccio
Nov 1, 1995·Physiology & Behavior·B B GorzalkaL A Hanson
Apr 4, 1998·Brain Research. Molecular Brain Research·M OsterlundY L Hurd

Citations

May 18, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nancy K MelloJack H Mendelson
Oct 1, 2009·Future Medicinal Chemistry·Cheryl A Frye
Sep 19, 2006·Pharmacology, Biochemistry, and Behavior·Cheryl A Frye
Jun 25, 2015·Regulatory Toxicology and Pharmacology : RTP·David V GauvinTheodore J Baird
Jan 1, 2014·Frontiers in Nutrition·Guido K W Frank

Related Concepts

Metazoa
Discrimination (Process of Differentiation)
Discrimination Learning
Hypothalamo-Hypophyseal System
Pituitary Hormones
Gonadal Steroid Hormones
Rats, Laboratory

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