Hormonoresistance in advanced breast cancer: a new revolution in endocrine therapy

Therapeutic Advances in Medical Oncology
Paule AugereauMario Campone

Abstract

Endocrine therapy is the mainstay of treatment of estrogen-receptor-positive (ER+) breast cancer with an overall survival benefit. However, some adaptive mechanisms in the tumor emerge leading to the development of a resistance to this therapy. A better characterization of this process is needed to overcome this resistance and to develop new tailored therapies. Mechanisms of resistance to hormone therapy result in activation of transduction signal pathways, including the cell cycle regulation with cyclin D/CDK4/6/Rb pathway. The strategy of combined hormone therapy with targeted agents has shown an improvement of progression-free survival (PFS) in several phase II or III trials, including three different classes of drugs: mTOR inhibitors, PI3K and CDK4/6 inhibitors. A recent phase III trial has shown that fulvestrant combined with a CDK 4/6 inhibitor doubles PFS in aromatase inhibitor-pretreated postmenopausal ER+ breast cancer. Other combinations are ongoing to disrupt the interaction between PI3K/AKT/mTOR and cyclin D/CDK4/6/Rb pathways. Despite these successful strategies, reliable and reproducible biomarkers are needed. Tumor genomics are dynamic over time, and blood-based biomarkers such as circulating tumor DNA represent ...Continue Reading

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Citations

May 17, 2018·Breast Cancer Research and Treatment·G HosteP Neven
Mar 2, 2019·International Journal of Molecular Sciences·Laura Rojas LorzJae Youl Cho
Mar 23, 2018·International Journal of Molecular Sciences·Se Eun ByeonJae Youl Cho
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Dec 17, 2017·Breast Cancer Research and Treatment·Pauline du RusquecJean-Sébastien Frenel
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May 18, 2021·Molecular and Cellular Endocrinology·Fahmida RashaKevin Pruitt
Aug 8, 2021·Cancers·Jéssica Fernanda BarazettiJaqueline Carvalho de Oliveira
Oct 9, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Ozge SaatciOzgur Sahin

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Methods Mentioned

BETA
biopsies

Clinical Trials Mentioned

NCT02216786

Software Mentioned

Horizon
BOLERO

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