PMID: 9165082Mar 1, 1997Paper

Horseshoe crab coagulogen is an invertebrate protein with a nerve growth factor-like domain

Biological Chemistry
A BergnerW Bode

Abstract

The rapid clotting of the horseshoe crab hemolymph is essential for both its host defense and hemostasis. It is mediated by the clotting cascade system which consists of four serine proteinase zymogens and the clottable protein coagulogen. Coagulogen, the target protein of the cascade, is converted to an insoluble gel upon activation of the cascade, giving rise to clot formation. Thus this cascade is reminiscent of the mammalian blood coagulation leading to fibrin clot. The structural analysis of coagulogen revealed a polypeptide fold and disulfide bridge pattern in the C-terminal half of the molecule very similar to nerve growth factor (NGF). This finding assigns coagulogen as the first structurally characterized invertebrate protein which belongs to the cystine knot superfamily. The putative structural similarity of coagulogen and the Drosophila morphogen Spaetzle as well as the homology of its processing proteinases suggests a common origin of the two functionally different cascades. This would exemplify a divergent evolution of two proteinase cascades having totally different functions from common ancestors in a long history of evolution.

References

Jun 1, 1995·Current Opinion in Structural Biology·N W Isaacs
Jan 1, 1995·Annual Review of Biophysics and Biomolecular Structure·P D Sun, D R Davies
Jun 9, 1994·Nature·A J LapthornN W Isaacs
Oct 1, 1993·Proteins·S DaopinD R Davies
Jan 1, 1993·Methods in Enzymology·T MutaS Iwanaga
Feb 1, 1993·Current Opinion in Immunology·S Iwanaga
Jul 1, 1996·Protein Science : a Publication of the Protein Society·P R MittlM G Grütter

❮ Previous
Next ❯

Citations

Oct 17, 2001·Developmental and Comparative Immunology·B G Magor, K E Magor
Jan 16, 2002·Current Opinion in Immunology·Sadaaki Iwanaga
Oct 6, 1999·Current Opinion in Neurobiology·F Hallböök
Mar 10, 2001·Trends in Cardiovascular Medicine·M M KremE Di Cera
Jul 2, 2002·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Gloria Yepiz-PlascenciaFrancisco Vargas-Albores
Nov 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·N KairiesS Kawabata
Jul 2, 2014·Seminars in Immunology·Tatsushi Igaki, Masayuki Miura
May 7, 2009·Cellular and Molecular Life Sciences : CMLS·Mitchell S Dushay
Nov 3, 2015·Journal of Immunotoxicology·Musa O SalawuAliyu O Amuzat
Apr 14, 2005·Journal of Biochemistry and Molecular Biology·Sadaaki Iwanaga, Bok Luel Lee
Jun 18, 2004·Immunological Reviews·Kei-ichiro InamoriShun-ichiro Kawabata
Jun 18, 2004·Immunological Reviews·George K ChristophidesFotis C Kafatos
Jan 29, 2002·Nature Immunology·Jules A Hoffmann, Jean-Marc Reichhart
May 3, 2003·Nature Reviews. Genetics·C Léopold Kurz, Jonathan J Ewbank
Aug 17, 2006·Brain, Behavior and Evolution·Wayne S Sossin
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·W C Aird
Jan 12, 2007·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Rasmus Skern-MauritzenFrank Nilsen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.